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Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflayonoids from Epimediums
Zhao, Haiyu; Fan, Miaoxuan; Fan, Li; Sun, Jianghao; Guo, Dean
关键词Epimediums Prenylflavonoids Metabolite profile HPLC-ESI-MS(n)
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2010-05-01
DOI10.1016/j.jchromb.2010.03.023
878期:15-16页:1113-1124
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]LIVER SUBCELLULAR PREPARATIONS ; GLUCURONO-CONJUGATION ; CULTURED-HEPATOCYTES ; FLAVONOL GLYCOSIDES ; SULFO-CONJUGATION ; ICARIIN ; DEGLYCOSYLATION ; ABSORPTION ; MECHANISM ; KOREANUM
英文摘要

The metabolites in rats after administration of icariside II, icariin, epimedin C and extracts of four Epimedium species were investigated. Feces, bile, plasma and urine samples were detected comprehensively using HPLC-ESI-MS(n) method. The structures of metabolites were identified on the basis of their characteristic fragmentations in MS(n) experiments. Totally, 54 metabolites were identified in these biosamples. Specific hydrolysis of 7-0 glucosides in gut lumen and glucuronic acid conjugation in liver were considered as the main physiologic processes of prenylflavonoids. Icariside II and anhydroicaritin were the major intermediate products in forming of mono- and di-glucuronic acid conjugations in vivo. In general, this study revealed the possible metabolite profiles of prenylflavonoids in rats, and might aid the clinical use of different Epimedium species. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000277672000013
项目编号985-2-063-112 ; 104218
资助机构Changjiang Scholars and Innovation Team in University ; Ministry of Education of China
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58570
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Haiyu,Fan, Miaoxuan,Fan, Li,et al. Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflayonoids from Epimediums[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2010,878(15-16):1113-1124.
APA Zhao, Haiyu,Fan, Miaoxuan,Fan, Li,Sun, Jianghao,&Guo, Dean.(2010).Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflayonoids from Epimediums.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,878(15-16),1113-1124.
MLA Zhao, Haiyu,et al."Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflayonoids from Epimediums".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 878.15-16(2010):1113-1124.
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