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学科主题: 药学
题名:
Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflayonoids from Epimediums
作者: Zhao, Haiyu; Fan, Miaoxuan; Fan, Li; Sun, Jianghao; Guo, Dean
关键词: Epimediums ; Prenylflavonoids ; Metabolite profile ; HPLC-ESI-MS(n)
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2010-05-01
DOI: 10.1016/j.jchromb.2010.03.023
卷: 878, 期:15-16, 页:1113-1124
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: LIVER SUBCELLULAR PREPARATIONS ; GLUCURONO-CONJUGATION ; CULTURED-HEPATOCYTES ; FLAVONOL GLYCOSIDES ; SULFO-CONJUGATION ; ICARIIN ; DEGLYCOSYLATION ; ABSORPTION ; MECHANISM ; KOREANUM
英文摘要:

The metabolites in rats after administration of icariside II, icariin, epimedin C and extracts of four Epimedium species were investigated. Feces, bile, plasma and urine samples were detected comprehensively using HPLC-ESI-MS(n) method. The structures of metabolites were identified on the basis of their characteristic fragmentations in MS(n) experiments. Totally, 54 metabolites were identified in these biosamples. Specific hydrolysis of 7-0 glucosides in gut lumen and glucuronic acid conjugation in liver were considered as the main physiologic processes of prenylflavonoids. Icariside II and anhydroicaritin were the major intermediate products in forming of mono- and di-glucuronic acid conjugations in vivo. In general, this study revealed the possible metabolite profiles of prenylflavonoids in rats, and might aid the clinical use of different Epimedium species. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 985-2-063-112 ; 104218
项目资助者: Changjiang Scholars and Innovation Team in University ; Ministry of Education of China
WOS记录号: WOS:000277672000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58570
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, Haiyu,Fan, Miaoxuan,Fan, Li,et al. Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflayonoids from Epimediums[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2010,878(15-16):1113-1124.
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