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学科主题临床医学
In Vitro Interaction of Itraconazole with Amphotericin B, Caspofungin, and Terbinafine Against Clinical Isolates of Trichosporon asahii
Li, Houmin1; Qiao, Jianjun2; Wan, Zhe3,4; Zhang, Jianzhong1
关键词Trichosporon asahii Antifungal susceptibility Drug interaction
刊名MYCOPATHOLOGIA
2011-05-01
DOI10.1007/s11046-010-9384-4
171期:5页:345-348
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
研究领域[WOS]Mycology
关键词[WOS]VORICONAZOLE ; COMBINATION ; EFFICACY ; FLUCONAZOLE ; ANTIFUNGALS ; MICAFUNGIN ; RESISTANT ; SYNERGY ; AZOLES ; YEAST
英文摘要

Treatment of disseminated trichosporosis is still challenging. Itraconazole is a widely used broad-spectrum antifungal drug. In vitro interactions of itraconazole (ICZ) with amphotericin B (AMB), caspofungin (CAS), and terbinafine (TBF) against 18 clinical isolates of Trichosporon asahii were assessed by chequerboard microdilution method. ICZ combined with CAS showed the highest percentage of synergistic effect (72.2%), followed by ICZ/AMB (11%) and ICZ/TBF (11%) combination. Antagonistic effect was not observed. This study demonstrates that itraconazole can enhance the antifungal activity of CAS against T. asahii, suggesting that this combination may be a potential strategy for treating disseminated trichosporosis.

语种英语
所属项目编号7073096
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
WOS记录号WOS:000289108200005
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58571
Collection北京大学第二临床医学院_皮科
作者单位1.Peking Univ, Res Ctr Med Mycol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
3.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Dermatol, Hangzhou 310003, Zhejiang, Peoples R China
4.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Li, Houmin,Qiao, Jianjun,Wan, Zhe,et al. In Vitro Interaction of Itraconazole with Amphotericin B, Caspofungin, and Terbinafine Against Clinical Isolates of Trichosporon asahii[J]. MYCOPATHOLOGIA,2011,171(5):345-348.
APA Li, Houmin,Qiao, Jianjun,Wan, Zhe,&Zhang, Jianzhong.(2011).In Vitro Interaction of Itraconazole with Amphotericin B, Caspofungin, and Terbinafine Against Clinical Isolates of Trichosporon asahii.MYCOPATHOLOGIA,171(5),345-348.
MLA Li, Houmin,et al."In Vitro Interaction of Itraconazole with Amphotericin B, Caspofungin, and Terbinafine Against Clinical Isolates of Trichosporon asahii".MYCOPATHOLOGIA 171.5(2011):345-348.
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