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学科主题: 临床医学
题名:
In Vitro Interaction of Itraconazole with Amphotericin B, Caspofungin, and Terbinafine Against Clinical Isolates of Trichosporon asahii
作者: Li, Houmin1; Qiao, Jianjun2; Wan, Zhe3,4; Zhang, Jianzhong1
关键词: Trichosporon asahii ; Antifungal susceptibility ; Drug interaction
刊名: MYCOPATHOLOGIA
发表日期: 2011-05-01
DOI: 10.1007/s11046-010-9384-4
卷: 171, 期:5, 页:345-348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: VORICONAZOLE ; COMBINATION ; EFFICACY ; FLUCONAZOLE ; ANTIFUNGALS ; MICAFUNGIN ; RESISTANT ; SYNERGY ; AZOLES ; YEAST
英文摘要:

Treatment of disseminated trichosporosis is still challenging. Itraconazole is a widely used broad-spectrum antifungal drug. In vitro interactions of itraconazole (ICZ) with amphotericin B (AMB), caspofungin (CAS), and terbinafine (TBF) against 18 clinical isolates of Trichosporon asahii were assessed by chequerboard microdilution method. ICZ combined with CAS showed the highest percentage of synergistic effect (72.2%), followed by ICZ/AMB (11%) and ICZ/TBF (11%) combination. Antagonistic effect was not observed. This study demonstrates that itraconazole can enhance the antifungal activity of CAS against T. asahii, suggesting that this combination may be a potential strategy for treating disseminated trichosporosis.

语种: 英语
所属项目编号: 7073096
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000289108200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58571
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Peking Univ, Res Ctr Med Mycol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
3.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Dermatol, Hangzhou 310003, Zhejiang, Peoples R China
4.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100044, Peoples R China

Recommended Citation:
Li, Houmin,Qiao, Jianjun,Wan, Zhe,et al. In Vitro Interaction of Itraconazole with Amphotericin B, Caspofungin, and Terbinafine Against Clinical Isolates of Trichosporon asahii[J]. MYCOPATHOLOGIA,2011,171(5):345-348.
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