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学科主题: 临床医学
题名:
Risk Factors for Postural Tachycardia Syndrome in Children and Adolescents
作者: Lin, Jing1; Han, Zhenhui2; Li, Xueying3; Ochs, Todd4; Zhao, Juan1; Zhang, Xi2; Yang, Jinyan1; Liu, Ping1; Xiong, Zhenyu2; Gai, Yong2; Tang, Chaoshu5; Du, Junbao1,6; Jin, Hongfang1
刊名: PLOS ONE
发表日期: 2014-12-04
DOI: 10.1371/journal.pone.0113625
卷: 9, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ORTHOSTATIC INTOLERANCE ; WATER DRINKING ; MIDODRINE HYDROCHLORIDE ; SYNDROME POTS ; THERAPEUTIC EFFECTIVENESS ; AUTONOMIC DYSFUNCTION ; SLEEP DISTURBANCES ; PLASMA COPEPTIN ; SYNCOPE ; HYPOVOLEMIA
英文摘要:

Background: Postural tachycardia syndrome (POTS) is prevalent in children and adolescents and has a great impact on health. But its risk factors have not been fully understood. This study aimed to explore possible risk factors for children and adolescents with POTS.

Methods and Findings: 600 children and adolescents (test group) aged 7-18 (11.9 +/- 3.0) years old, 259 males and 341 females, were recruited for identifying its risk factors. Another 197 subjects aged from 7 to 18 (11.3 +/- 2.3) years old were enrolled in the validation group. Heart rate (HR) and blood pressure (BP) were monitored during upright test. Risk factors were analyzed and sensitivity and specificity for predicting POTS were tested via receiver operating characteristic curve. Among 600 subjects, 41 were confirmed with POTS patients (6.8%) based on clinical manifestation and upright test. The results showed a significant difference in daily water intake, the daily sleeping hours, supine HR, HR increment and maximum HR during upright test between POTS and the unaffected children (P<0.05). Likelihood of POTS would increase by 1.583 times if supine HR was increased by 10 beats/min (95%CI 1.184 to 2.116, P<0.01), by 3.877 times if a child′s water intake was less than 800 ml/day (95%CI 1.937 to 7.760, P<0.001), or by 5.905 times (95%CI 2.972 to 11.733, P<0.001) if sleeping hours were less than 8 hours/day. Supine HR, daily water intake and sleeping hours showed the capability of predicting POTS in children and adolescents with an AUC of 83.9% (95% CI: 78.6%-89.1%), sensitivity of 80.5% and specificity of 75%. Furthermore, in validation group, predictive sensitivity and specificity were 73.3% and 72.5%.

Conclusion: Faster supine HR, less water intake and shorter sleeping hours were identified as risk factors for POTS.

语种: 英语
所属项目编号: 2012BAI03B03 ; 2012CB517806 ; 2011CB503904 ; 81121061
项目资助者: National Twelfth Five-Year Plan for Science &amp ; Technology Support ; Ministry of Science and Technology, P.R. China ; Major Basic Research Project of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号: WOS:000346382500087
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58574
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100871, Peoples R China
2.Childrens Hosp Kaifeng, Dept Pediat, Zhengzhou, Henan, Peoples R China
3.Peking Univ, Dept Med Stat, Hosp 1, Beijing 100871, Peoples R China
4.Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA
5.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
6.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Jing,Han, Zhenhui,Li, Xueying,et al. Risk Factors for Postural Tachycardia Syndrome in Children and Adolescents[J]. PLOS ONE,2014,9(12).
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