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学科主题: 临床医学
题名:
Expression and Localization of TLR4 and Its Negative Regulator Tollip in the Placenta of Early-Onset and Late-Onset Preeclampsia
作者: Zhang, Li; Yang, Huixia
关键词: Preeclampsia ; Placenta ; Inflammation ; Innate immune
刊名: HYPERTENSION IN PREGNANCY
发表日期: 2012
DOI: 10.3109/10641955.2011.642434
卷: 31, 期:2, 页:218-227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Physiology ; Peripheral Vascular Disease
研究领域[WOS]: Obstetrics & Gynecology ; Physiology ; Cardiovascular System & Cardiology
关键词[WOS]: IMMUNE-SYSTEM ; RECEPTORS ; PREGNANCY ; RESPONSES ; TOLL-LIKE-RECEPTOR-4 ; LIGANDS ; CELLS ; TERM
英文摘要:

Objective. Toll-like receptor 4 (TLR4) is a key component of the innate arm of the immune system that mediates inflammatory responses following exposure to bacterial lipopolysaccharides. In doing so, TLR4 may contribute to the pathogenesis of preeclampsia (PE). We sought to assess the spatio-temporal expression of TLR4 and its negative regulator Toll-interacting protein (Tollip) in placental tissues from normal and preeclamptic pregnancies. Methods. Using immunohistochemistry and immunoblotting, we investigated the localization of TLR4 and its negative regulator Tollip in first- and third-trimester human placenta. Results. TLR4 was found to be expressed in the cytoplasm of trophoblasts in both first- (n = 6) and third-trimester (n = 24) placental villous samples. Tollip was mainly located in the cytoplasm of cytotrophoblasts in the first-trimester placental tissues; in contrast, our analyses of third-trimester placental tissues demonstrated that Tollip was mainly located in the decidual cells. Using western blot analysis, TLR4 expression was shown to be significantly higher in early-onset PE tissues than control group placentas (n = 8 for each group, p < 0.01). However, we were unable to detect a significant difference between late-onset PE and normal controls (n = 8 for each group, p = 0.119). Conclusion. These data demonstrate the novel observation that TLR4 may play a much more important role in early-onset PE. Interestingly, the spatial expression of Tollip at different stages of gestation may play an important role in the pathophysiology of PE.

语种: 英语
WOS记录号: WOS:000303292500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58576
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Dept Obstet & Gynecol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Li,Yang, Huixia. Expression and Localization of TLR4 and Its Negative Regulator Tollip in the Placenta of Early-Onset and Late-Onset Preeclampsia[J]. HYPERTENSION IN PREGNANCY,2012,31(2):218-227.
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