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学科主题临床医学
Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment
Hou, Yi-Bin; Chen, Min-Hua; Yan, Kun; Wu, Jin-Yu; Yang, Wei
关键词Hepatocellular carcinoma Feeding artery Radiofrequency ablation Recurrence Color Doppler flow imaging
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2009-06-07
DOI10.3748/wjg.15.2638
15期:21页:2638-2643
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者BMSTC ; National High Technology Research and Development Program of China ; BMSTC ; National High Technology Research and Development Program of China
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]HEPATIC BLOOD-FLOW ; THERMAL ABLATION ; TISSUE ABLATION ; LIVER ; OCCLUSION ; THERAPY ; TUMORS ; CHEMOEMBOLIZATION ; MALIGNANCIES ; ELECTRODE
英文摘要

AIM: To evaluate the feasibility and efficacy of percutaneous radiofrequency ablation (RFA) of the feeding artery of hepatocellular carcinoma (HCC) in reducing the blood-flow-induced heat-sink effect of RFA.

METHODS: A total of 154 HCC patients with 177 pathologically confirmed hypervascular lesions participated in the study and were randomly assigned into two groups. Seventy-one patients with 75 HCCs (average tumor size, 4.3 +/- 1.1 cm) were included in group A, in which the feeding artery of HCC was identified by color Doppler flow imaging, and were ablated with multiple small overlapping RFA foci [percutaneous ablation of feeding artery (PAA)] before routine RFA treatment of the tumor. Eighty-three patients with 102 HCC (average tumor size, 4.1 +/- 1.0 cm) were included in group B, in which the tumors were treated routinely with RFA. Contrast-enhanced computed tomography was used as post-RFA imaging, when patients were followed-up for 1, 3 and 6 mo.

RESULTS: In group A, feeding arteries were blocked in 66 (88%) HCC lesions, and the size of arteries decreased in nine (12%). The average number of punctures per HCC was 2.76 +/- 1.12 in group A, and 3.36 +/- 1.60 in group B (P = 0.01). The tumor necrosis rate at 1 mo post-RFA was 90.67% (68/75 lesions) in group A and 90.20% (92/102 lesions) in group B. HCC recurrence rate at 6 mo post-RFA was 17.33% (13/75) in group A and 31.37% (32/102) in group B (P = 0.04).

CONCLUSION: PAA blocked effectively the feeding artery of HCC. Combination of PAA and RFA significantly decreased post-RFA recurrence and provided an alternative treatment for hypervascular HCC. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种英语
所属项目编号Z0005190040431 ; 2007AA02Z4B8
资助者BMSTC ; National High Technology Research and Development Program of China ; BMSTC ; National High Technology Research and Development Program of China
WOS记录号WOS:000266786300012
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58577
专题北京大学临床肿瘤学院_超声科
作者单位Peking Univ, Canc Hosp & Inst, Sch Oncol, Dept Ultrasound, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Hou, Yi-Bin,Chen, Min-Hua,Yan, Kun,et al. Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(21):2638-2643.
APA Hou, Yi-Bin,Chen, Min-Hua,Yan, Kun,Wu, Jin-Yu,&Yang, Wei.(2009).Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment.WORLD JOURNAL OF GASTROENTEROLOGY,15(21),2638-2643.
MLA Hou, Yi-Bin,et al."Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment".WORLD JOURNAL OF GASTROENTEROLOGY 15.21(2009):2638-2643.
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