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学科主题: 临床医学
题名:
Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment
作者: Hou, Yi-Bin; Chen, Min-Hua; Yan, Kun; Wu, Jin-Yu; Yang, Wei
关键词: Hepatocellular carcinoma ; Feeding artery ; Radiofrequency ablation ; Recurrence ; Color Doppler flow imaging
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2009-06-07
DOI: 10.3748/wjg.15.2638
卷: 15, 期:21, 页:2638-2643
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HEPATIC BLOOD-FLOW ; THERMAL ABLATION ; TISSUE ABLATION ; LIVER ; OCCLUSION ; THERAPY ; TUMORS ; CHEMOEMBOLIZATION ; MALIGNANCIES ; ELECTRODE
英文摘要:

AIM: To evaluate the feasibility and efficacy of percutaneous radiofrequency ablation (RFA) of the feeding artery of hepatocellular carcinoma (HCC) in reducing the blood-flow-induced heat-sink effect of RFA.

METHODS: A total of 154 HCC patients with 177 pathologically confirmed hypervascular lesions participated in the study and were randomly assigned into two groups. Seventy-one patients with 75 HCCs (average tumor size, 4.3 +/- 1.1 cm) were included in group A, in which the feeding artery of HCC was identified by color Doppler flow imaging, and were ablated with multiple small overlapping RFA foci [percutaneous ablation of feeding artery (PAA)] before routine RFA treatment of the tumor. Eighty-three patients with 102 HCC (average tumor size, 4.1 +/- 1.0 cm) were included in group B, in which the tumors were treated routinely with RFA. Contrast-enhanced computed tomography was used as post-RFA imaging, when patients were followed-up for 1, 3 and 6 mo.

RESULTS: In group A, feeding arteries were blocked in 66 (88%) HCC lesions, and the size of arteries decreased in nine (12%). The average number of punctures per HCC was 2.76 +/- 1.12 in group A, and 3.36 +/- 1.60 in group B (P = 0.01). The tumor necrosis rate at 1 mo post-RFA was 90.67% (68/75 lesions) in group A and 90.20% (92/102 lesions) in group B. HCC recurrence rate at 6 mo post-RFA was 17.33% (13/75) in group A and 31.37% (32/102) in group B (P = 0.04).

CONCLUSION: PAA blocked effectively the feeding artery of HCC. Combination of PAA and RFA significantly decreased post-RFA recurrence and provided an alternative treatment for hypervascular HCC. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种: 英语
所属项目编号: Z0005190040431 ; 2007AA02Z4B8
项目资助者: BMSTC ; National High Technology Research and Development Program of China
WOS记录号: WOS:000266786300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58577
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: Peking Univ, Canc Hosp & Inst, Sch Oncol, Dept Ultrasound, Beijing 100142, Peoples R China

Recommended Citation:
Hou, Yi-Bin,Chen, Min-Hua,Yan, Kun,et al. Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(21):2638-2643.
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