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Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)
Zhu, Jiadan1; Ji, Zhiqiang1; Wang, Jing1; Sun, Ronghua1; Zhang, Xiang1; Gao, Yang1; Sun, Hongfang1; Liu, Yuanfang1,3; Wang, Zheng2; Li, Aidong2; Ma, Jie2; Wang, Tiancheng4; Jia, Guang4; Gu, Yiqun5
关键词antitumor agents fullerol immunology macrophages toxicology
刊名SMALL
2008-08-01
DOI10.1002/smll.200701219
4期:8页:1168-1175
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
资助者China Natural Science Foundation ; China Ministry of Science and Technology ; China Natural Science Foundation ; China Ministry of Science and Technology
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]MURINE PERITONEAL-MACROPHAGES ; NITRIC-OXIDE SYNTHASE ; IN-VITRO ; ANTITUMOR-ACTIVITY ; BIOLOGICAL APPLICATIONS ; ALVEOLAR MACROPHAGES ; C-60 ; DERIVATIVES ; TOXICITY ; CELLS
英文摘要

The tumor-inhibitory effect of C-60(OH)(x) was tested on the murine H22 hepatocarcinoma model. Doses of 0.2 and 1.0 mg kg(-1) body weight both showed significant antitumor activity with tumor inhibition rates of 31.9 and 38.4%, respectively, when mice were treated for 17 consecutive days. The damnification of liver was prominently reduced. Furthermore, histological examination indicated that an envelope of fibroblasts and lymphocytes was formed surrounding tumor tissues in the C-60(OH)(x)-treated group, which inhibited the infiltration of tumor to the neighboring normal skeleton muscle tissues. To understand the antitumor mechanism, the immunomodulatory activity of C-60(OH)(x) was investigated. The results indicate that C-60(OH)(x) enhances the phagocytosis of peritoneal macrophages and elevates the activity of arginase and acid phosphatase in vivo. The tumor necrosis factor alpha production of C-60(OH)(x)-treated macrophages also increases in vitro. These results suggest that C-60(OH)(x) can enhance the innate immunity of tumor-bearing mice, and therefore inhibits growth of the tumor.

语种英语
所属项目编号10490180 ; 90406024-5 ; 2006CB705604
资助者China Natural Science Foundation ; China Ministry of Science and Technology ; China Natural Science Foundation ; China Ministry of Science and Technology
WOS记录号WOS:000258566400026
引用统计
被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58591
专题北京大学公共卫生学院
作者单位1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Union Med Coll, Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100083, Peoples R China
5.HaiDian Maternal & Child Hlth Hosp, Dept Pathol, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Jiadan,Ji, Zhiqiang,Wang, Jing,et al. Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)[J]. SMALL,2008,4(8):1168-1175.
APA Zhu, Jiadan.,Ji, Zhiqiang.,Wang, Jing.,Sun, Ronghua.,Zhang, Xiang.,...&Gu, Yiqun.(2008).Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x).SMALL,4(8),1168-1175.
MLA Zhu, Jiadan,et al."Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)".SMALL 4.8(2008):1168-1175.
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