|A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation|
|Lin, Qing1; Jia, Lina2; Sun, Yanshu1|
|关键词||atrial fibrillation peroxisome proliferator-activated receptor-gamma inflammation|
|刊名||ARCHIVES OF MEDICAL SCIENCE|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||C-REACTIVE PROTEIN ; PIOGLITAZONE ; MECHANISMS ; INFLAMMATION ; METAANALYSIS ; INSIGHTS|
Introduction: The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor-gamma (PPAR-gamma) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).
Material and methods: We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-gamma receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.
Results: The concentration of PPAR-gamma receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-alpha were higher than those in the control group (all p < 0.01). The PPAR-gamma level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-gamma, hs-CRP, TNF-alpha and LAD level were associated with AF.
Conclusions: Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-gamma receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-gamma may take part in the pathogenesis of AF.
|作者单位||1.Peking Univ First Hosp, Dept Geriatr, Beijing, Peoples R China|
2.Beijing Shijitan Hosp, Dept Geriatr, Beijing, Peoples R China
|Lin, Qing,Jia, Lina,Sun, Yanshu. A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation[J]. ARCHIVES OF MEDICAL SCIENCE,2012,8(3):471-476.|
|APA||Lin, Qing,Jia, Lina,&Sun, Yanshu.(2012).A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation.ARCHIVES OF MEDICAL SCIENCE,8(3),471-476.|
|MLA||Lin, Qing,et al."A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation".ARCHIVES OF MEDICAL SCIENCE 8.3(2012):471-476.|