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学科主题: 临床医学
题名:
A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation
作者: Lin, Qing1; Jia, Lina2; Sun, Yanshu1
关键词: atrial fibrillation ; peroxisome proliferator-activated receptor-gamma ; inflammation
刊名: ARCHIVES OF MEDICAL SCIENCE
发表日期: 2012-06-01
DOI: 10.5114/aoms.2012.29402
卷: 8, 期:3, 页:471-476
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: C-REACTIVE PROTEIN ; PIOGLITAZONE ; MECHANISMS ; INFLAMMATION ; METAANALYSIS ; INSIGHTS
英文摘要:

Introduction: The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor-gamma (PPAR-gamma) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).

Material and methods: We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-gamma receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.

Results: The concentration of PPAR-gamma receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-alpha were higher than those in the control group (all p < 0.01). The PPAR-gamma level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-gamma, hs-CRP, TNF-alpha and LAD level were associated with AF.

Conclusions: Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-gamma receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-gamma may take part in the pathogenesis of AF.

语种: 英语
WOS记录号: WOS:000306150200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58596
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Dept Geriatr, Beijing, Peoples R China
2.Beijing Shijitan Hosp, Dept Geriatr, Beijing, Peoples R China

Recommended Citation:
Lin, Qing,Jia, Lina,Sun, Yanshu. A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation[J]. ARCHIVES OF MEDICAL SCIENCE,2012,8(3):471-476.
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