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学科主题临床医学
A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation
Lin, Qing1; Jia, Lina2; Sun, Yanshu1
关键词atrial fibrillation peroxisome proliferator-activated receptor-gamma inflammation
刊名ARCHIVES OF MEDICAL SCIENCE
2012-06-01
DOI10.5114/aoms.2012.29402
8期:3页:471-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]C-REACTIVE PROTEIN ; PIOGLITAZONE ; MECHANISMS ; INFLAMMATION ; METAANALYSIS ; INSIGHTS
英文摘要

Introduction: The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor-gamma (PPAR-gamma) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).

Material and methods: We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-gamma receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.

Results: The concentration of PPAR-gamma receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-alpha were higher than those in the control group (all p < 0.01). The PPAR-gamma level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-gamma, hs-CRP, TNF-alpha and LAD level were associated with AF.

Conclusions: Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-gamma receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-gamma may take part in the pathogenesis of AF.

语种英语
WOS记录号WOS:000306150200013
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58596
专题北京大学第一临床医学院_老年病内科
作者单位1.Peking Univ First Hosp, Dept Geriatr, Beijing, Peoples R China
2.Beijing Shijitan Hosp, Dept Geriatr, Beijing, Peoples R China
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Lin, Qing,Jia, Lina,Sun, Yanshu. A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation[J]. ARCHIVES OF MEDICAL SCIENCE,2012,8(3):471-476.
APA Lin, Qing,Jia, Lina,&Sun, Yanshu.(2012).A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation.ARCHIVES OF MEDICAL SCIENCE,8(3),471-476.
MLA Lin, Qing,et al."A pilot study of circulating PPAR-gamma receptor protein in elderly patients with atrial fibrillation".ARCHIVES OF MEDICAL SCIENCE 8.3(2012):471-476.
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