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学科主题: 临床医学
题名:
Cytomegalovirus is a potential risk factor for late-onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation
作者: Han, Ting-Ting; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Fu, Hai-Xia; Zhao, Xiang-Yu; Zhao, Xiao-Su; Huang, Xiao-Jun
刊名: AMERICAN JOURNAL OF HEMATOLOGY
发表日期: 2014
DOI: 10.1002/ajh.23584
卷: 89, 期:1, 页:55-61
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; HIGH-DOSE CHEMOTHERAPY ; VERSUS-HOST-DISEASE ; BK VIRUS LOAD ; CMV REACTIVATION ; HEMATOLOGICAL MALIGNANCIES ; ASSOCIATION ; CHILDREN ; ADENOVIRUS ; RECIPIENTS
英文摘要:

Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is primarily associated with viral infection. We prospectively quantified cytomegalovirus (CMV), BK virus (BKV), and adenovirus in urine and plasma using Q-RT-PCR in 50 consecutive patients to define the relationship between virus and LOHC. Of the 50 patients, 21 developed LOHC at a median of 29 days (range 4-64 days), with a cumulative incidence of 42% (+/- 7.1%). The cumulative incidence of LOHC on day 100 in patients with and without CMV viremia (prior to or at the onset of LOHC) were 56.3% (+/- 8.9%) and 16.7% (+/- 9.1%) (P = 0.018), respectively, and it was 59.3% (+/- 9.8%) and 21.7% (+/- 8.8%) in patients with and without CMV viruria (prior to or at the onset of LOHC) (P = 0.021), respectively. The cumulative incidence of LOHC was also higher in patients with a plasma BKV load increased 3 log(10) or with a urine BKV load increased 4 log(10) than those without the increase (P < 0.001). Only one patient with LOHC was tested positive for ADV. Both the univariate and multivariate analyses showed that CMV viremia (HR = 3.461, 95% CI: 1.005-11.922, P = 0.049) and a plasma BKV load that was increased 3 log(10) (HR = 10.705, 95%CI: 2.469-46.420, P = 0.002) were independent risk factors for the development of LOHC. We conclude that both CMV viremia and an increase of plasma BKV are independent risk factors for LOHC. And the role of CMV viremia was firstly demonstrated. Am. J. Hematol. 89:55-61, 2014. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 81230013 ; 30725038 ; 7122193 ; 2011AA020105
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; National High Technology Research and Development Program of China (Program 863) ; Ministry of Health
WOS记录号: WOS:000330093900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58607
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Han, Ting-Ting,Xu, Lan-Ping,Liu, Dai-Hong,et al. Cytomegalovirus is a potential risk factor for late-onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation[J]. AMERICAN JOURNAL OF HEMATOLOGY,2014,89(1):55-61.
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