|Treatment of Severe Keratoconjunctivitis Sicca by Parotid Duct Transposition after Tympanic Neurectomy in Rabbits|
|Chen, Zhi-yuan1,2,3; Jie, Ying4,5; Yu, Guang-yan1,2|
|刊名||INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE|
|WOS标题词||Science & Technology|
|关键词[WOS]||SUBMANDIBULAR-GLAND TRANSFER ; TERM-FOLLOW-UP ; TOTAL XEROPHTHALMIA ; SURGICAL-TREATMENT ; SALIVARY-GLAND ; MANAGEMENT ; TRANSPLANTATION ; MODEL ; SIALORRHEA ; SECONDARY|
PURPOSE. To investigate the feasibility of parotid duct transposition after tympanic neurectomy to treat severe keratoconjunctivitis sicca (KCS) in rabbits.
METHODS. Thirty rabbits were divided into three groups in experiment 1. One eye was operated on, and the contralateral eye served as the control. In the KCS group, the lacrimal gland, harderian gland, and nictitating membrane were removed. In the group with parotid duct transposition (DT), the parotid duct was transposed into the lower conjunctival fornix. In the group with parotid duct transposition after tympanic neurectomy (DTTN), the tympanic nerve was resected in addition to parotid duct transposition. Schirmer test was performed and density of corneal staining was determined monthly after surgery, and goblet cell density was measured at postoperative month 3. In experiment 2, the tympanic nerve was resected on one side in 12 rabbits. Both sides of the parotid gland were resected for histopathology at intervals of 2 months to 1 year after surgery.
RESULTS. Tear secretion from operated eyes at rest increased significantly after surgery in the treatment groups compared with the KCS group. Tear secretion from operated eyes after chewing was significantly lower in the DTTN than in the DT group. The corneal staining scores were higher in the operated than in the control eyes of the three groups, without significant difference among the operated eyes. Parotid gland atrophy on the operated side occurred at postoperative month 4 and recovered to normal 1 year after surgery.
CONCLUSIONS. Parotid duct transposition after tympanic neurectomy could effectively reduce gustatory epiphora but may be insufficient to promote ocular surface health. (Invest Ophthalmol Vis Sci. 2011;52:6964-6970) DOI:10.1167/iovs.10-6459
|项目编号||30370102 ; 81070847 ; 2007BAI18B11|
|资助机构||Natural Science Foundation of China ; National Supporting Program for Science and Technology|
|作者单位||1.Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China|
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Peking Univ, Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
4.Capital Med Univ, Beijing Tongren Hosp, Dept Stomatol, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China
|Chen, Zhi-yuan,Jie, Ying,Yu, Guang-yan. Treatment of Severe Keratoconjunctivitis Sicca by Parotid Duct Transposition after Tympanic Neurectomy in Rabbits[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2011,52(9):6964-6970.|
|APA||Chen, Zhi-yuan,Jie, Ying,&Yu, Guang-yan.(2011).Treatment of Severe Keratoconjunctivitis Sicca by Parotid Duct Transposition after Tympanic Neurectomy in Rabbits.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,52(9),6964-6970.|
|MLA||Chen, Zhi-yuan,et al."Treatment of Severe Keratoconjunctivitis Sicca by Parotid Duct Transposition after Tympanic Neurectomy in Rabbits".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52.9(2011):6964-6970.|