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学科主题: 临床医学
题名:
Correlation of pulmonary functions of COPD patients to those of their first-degree children
作者: Lu, BB; He, QY
关键词: lung disease ; obstructive ; cigarette smoking ; disease susceptibility
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2003-07-01
卷: 116, 期:7, 页:991-995
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CHRONIC-BRONCHITIS ; GENETIC EPIDEMIOLOGY ; DISEASE ; POLYMORPHISM ; EMPHYSEMA
英文摘要:

Objective To assess the risk factors correlating to the likelihood for airflow obstruction among first-degree children of chronic obstructive pulmonary disease ( COPD) patients and whether familial aggregation of pulmonary function abnormality exists.

Methods Fifty-nine smokers with COPD and 28 smokers without COPD as control and all their children available were recruited into the study. Their history was recorded and a binary logistic regression analysis was carried out to ascertain the effects of their relationship to a proband with COPD, when other potential risk factors were controlled.

Results Children with COPD probands showed increased risk of FEV1 below the 70% predicted (OR = 1.987) after accounting for the effects of smoking, sex and clinical symptoms. The lower the pulmonary function of the COPD proband, the higher the risk to their children for FEV1 below the 70% predicted.

Conclusions Our finding demonstrates the presence of a household aggregation inclination of COPD and pulmonary function impairment. Genetic factors might act as the basis of the familial aggregation.

语种: 英语
WOS记录号: WOS:000184621800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58612
Appears in Collections:北京大学第二临床医学院_呼吸内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Resp Med, Beijing 100044, Peoples R China

Recommended Citation:
Lu, BB,He, QY. Correlation of pulmonary functions of COPD patients to those of their first-degree children[J]. CHINESE MEDICAL JOURNAL,2003,116(7):991-995.
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