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学科主题临床医学
Correlation of pulmonary functions of COPD patients to those of their first-degree children
Lu, BB; He, QY
关键词lung disease obstructive cigarette smoking disease susceptibility
刊名CHINESE MEDICAL JOURNAL
2003-07-01
116期:7页:991-995
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CHRONIC-BRONCHITIS ; GENETIC EPIDEMIOLOGY ; DISEASE ; POLYMORPHISM ; EMPHYSEMA
英文摘要

Objective To assess the risk factors correlating to the likelihood for airflow obstruction among first-degree children of chronic obstructive pulmonary disease ( COPD) patients and whether familial aggregation of pulmonary function abnormality exists.

Methods Fifty-nine smokers with COPD and 28 smokers without COPD as control and all their children available were recruited into the study. Their history was recorded and a binary logistic regression analysis was carried out to ascertain the effects of their relationship to a proband with COPD, when other potential risk factors were controlled.

Results Children with COPD probands showed increased risk of FEV1 below the 70% predicted (OR = 1.987) after accounting for the effects of smoking, sex and clinical symptoms. The lower the pulmonary function of the COPD proband, the higher the risk to their children for FEV1 below the 70% predicted.

Conclusions Our finding demonstrates the presence of a household aggregation inclination of COPD and pulmonary function impairment. Genetic factors might act as the basis of the familial aggregation.

语种英语
WOS记录号WOS:000184621800010
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58612
专题北京大学第二临床医学院_呼吸科
作者单位Peking Univ, Peoples Hosp, Dept Resp Med, Beijing 100044, Peoples R China
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GB/T 7714
Lu, BB,He, QY. Correlation of pulmonary functions of COPD patients to those of their first-degree children[J]. CHINESE MEDICAL JOURNAL,2003,116(7):991-995.
APA Lu, BB,&He, QY.(2003).Correlation of pulmonary functions of COPD patients to those of their first-degree children.CHINESE MEDICAL JOURNAL,116(7),991-995.
MLA Lu, BB,et al."Correlation of pulmonary functions of COPD patients to those of their first-degree children".CHINESE MEDICAL JOURNAL 116.7(2003):991-995.
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