IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Prognostic factors of oncological and reproductive outcomes in fertility-sparing treatment of complex atypical hyperplasia and low-grade endometrial cancer using oral progestin in Chinese patients
Zhou Rong; Yang Yuan; Lu Qun; Wang Jianliu; Miao Yali; Wang Shijun; Wang Zhiqi; Zhao Chao; Wei Lihui
关键词Endometrial cancer Endometrial atypical hyperplasia Fertility-sparing treatment Progestin therapy Metformin Pcos
刊名GYNECOLOGIC ONCOLOGY
2015-12-01
DOI10.1016/j.ygyno.2015.09.078
139期:3页:424-428
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]POLYCYSTIC-OVARY-SYNDROME ; YOUNG-WOMEN ; CONSERVATIVE THERAPY ; PREMENOPAUSAL WOMEN ; UTERINE-CANCER ; MANAGEMENT ; CARCINOMA ; ADENOCARCINOMA ; ASSOCIATION ; METFORMIN
英文摘要

Objective. To evaluate the efficacy and fertility outcomes of progestin treatment for complex atypical hyperplasia (CAH)/grade I endometrial cancer (G1EC) in Chinese patients (<= 40 years old).

Methods. Women <= 40 years old who were treated with progestin for CAH or G1EC were identified from 9 provinces of China The time to achieve complete response (CR) and the time from CR to recurrence or pregnancy were censored for patients without events and were analyzed for associations between patient and treatment characteristics.

Results. Thirty-two patients were included: 13 with CAH and 19 with G1EC. Nine patients exhibited elevated serum HbA(1)C before treatment After a mean follow-up of 32.5 months, the CR rate was 84.4%. Patients who exhibited elevated HbA(1)C were more likely to experience CR, while those with polycystic ovarian syndrome (PCOS) exhibited the opposite outcome (p = 0.01, 0.03). Nine of 21 patients experienced clinical pregnancies. Eight patients underwent assisted reproductive technology (ART). Five patients had newborn infants. Patients undergoing ART were more likely to become pregnant (p = 0.04).

Conclusion. Oral progestin is an effective fertility-sparing treatment for women with CAH/G1EC in China Patients with elevated HbA(1)C receiving both metformin and progestin were more likely to achieve CR, whereas those with PCOS were not. ART is a good choice for clinical pregnancy after treatment. (C) 2015 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000366618900008
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58613
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou Rong,Yang Yuan,Lu Qun,et al. Prognostic factors of oncological and reproductive outcomes in fertility-sparing treatment of complex atypical hyperplasia and low-grade endometrial cancer using oral progestin in Chinese patients[J]. GYNECOLOGIC ONCOLOGY,2015,139(3):424-428.
APA Zhou Rong.,Yang Yuan.,Lu Qun.,Wang Jianliu.,Miao Yali.,...&Wei Lihui.(2015).Prognostic factors of oncological and reproductive outcomes in fertility-sparing treatment of complex atypical hyperplasia and low-grade endometrial cancer using oral progestin in Chinese patients.GYNECOLOGIC ONCOLOGY,139(3),424-428.
MLA Zhou Rong,et al."Prognostic factors of oncological and reproductive outcomes in fertility-sparing treatment of complex atypical hyperplasia and low-grade endometrial cancer using oral progestin in Chinese patients".GYNECOLOGIC ONCOLOGY 139.3(2015):424-428.
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