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学科主题: 临床医学
题名:
Heart failure after allogeneic hematopoietic stem cell transplantation
作者: Mo, Xiao-Dong; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Chen, Huan; Chen, Yu-Hong; Han, Wei; Wang, Yu; Wang, Feng-Rong; Wang, Jing-Zhi; Zhao, Ting; Yan, Chen-Hua; Sun, Yu-Qian; Liu, Kai-Yan; Huang, Xiao-Jun1
关键词: Heart failure ; Allogeneic hematopoietic stem ; Transplant-related complication
刊名: INTERNATIONAL JOURNAL OF CARDIOLOGY
发表日期: 2013-09-10
DOI: 10.1016/j.ijcard.2012.06.021
卷: 167, 期:6, 页:2502-2506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; HIGH-DOSE CYCLOPHOSPHAMIDE ; VERSUS-HOST-DISEASE ; CARDIAC COMPLICATIONS ; CHILDHOOD-CANCER ; PREDICTIVE-VALUE ; ONCOLOGY-GROUP ; ACUTE GVHD ; CARDIOTOXICITY ; THERAPY
英文摘要:

Background: Heart failure (HF) occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare but severe. We examine the role of pre-HSCT therapeutic exposures, conditioning regimens, pre-HSCT comorbidities, severe transplant-related complications, and post-HSCT cardiovascular risk factors in the development of heart failure after allo-HSCT.

Methods: A nested case-control study was designed. Cases with HF and controls matched for age, year of allo-HSCT, and length of follow-up were identified from a cohort of 2455 patients who underwent allo-HSCT between 2000 and 2011 for hematologic malignancies.

Results: Forty-two patients suffered from HF; mean age at presentation was 35 years (+/- 14 years) and mean time to presentation was 5 months (+/- 9 months) post-HSCT. The number of pre-HSCT cycles of chemotherapy was significantly greater (7 vs. 5 courses, P=0.023). Cases were significantly more likely to have severe acute GVHD (>= grade III), hemorrhagic cystitis (>= grade 2), and multiple severe transplant-related complications compared with controls (42.9% vs. 20.4%, P=0.008). Multivariate analysis revealed that pre-HSCT cycles of chemotherapy of >= 5 courses (OR=3.5, P=0.003) and two or more severe transplant-related complications (OR=3.6, P=0.003) were independently associated with HF.

Conclusions: These results identify the individuals who are at higher risk of developing HF after allo-HSCT. We should pay more attention to these patients and more active management would be reasonable. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011AA020105 ; 30971292
项目资助者: National High Technology Research and Development Program of China (Program 863) ; National Natural Science Foundation of China
WOS记录号: WOS:000324478400035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58614
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing Key Lab Hematopoit Stem Cell Transplantat, Beijing 100044, Peoples R China
2.Inst Hematol, Beijing Key Lab Hematopoit Stem Cell Transplantat, Beijing 100044, Peoples R China

Recommended Citation:
Mo, Xiao-Dong,Xu, Lan-Ping,Liu, Dai-Hong,et al. Heart failure after allogeneic hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,2013,167(6):2502-2506.
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