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学科主题: 基础医学
题名:
High-resolution genome-wide analysis identified recurrent genetic alterations in NK/T-cell lymphoma, nasal type, which are associated with disease progression
作者: Sun, Lin1; Li, Min1; Huang, Xin1; Xu, Jiaosheng2; Gao, Zifen1; Liu, Cuiling1
关键词: Extranodal NK/T-cell lymphoma, nasal type ; Array CGH ; Genetic alterations ; 8p11.23
刊名: MEDICAL ONCOLOGY
发表日期: 2014-07-01
DOI: 10.1007/s12032-014-0071-z
卷: 31, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CONSISTENT PATTERNS ; HYBRIDIZATION ; LYMPHOMA/LEUKEMIA ; TRANSPORTERS ; IMMUNITY
英文摘要:

Extranodal NK/T-cell lymphoma, nasal type, is an aggressive mature NK-cell/T-cell lymphoma. Using array-based comparative genomic hybridization (array CGH) assays, we screened genomic alterations and potential candidate genes implicated in pathogenesis, progression, and prognosis. Our array CGH analysis detected an average of 83 chromosomal aberrations in 13 cases, ranging from 0 to 387. There were 177 recurrent chromosomal gains and 35 recurrent losses. Eleven gains and 14 losses were detected in more than 30 % of the cases, including gains of 3q26.1, 7q34, and 8q24.3 and losses of 15q24.2, 19q13.32, 5p13.2, and 14q21.1. The most common losses were observed in the 15q24.2 and 19q13.32 regions (9 cases, 69.2 %, respectively). Loss of 8p11.23 was associated with significant poor survival (P = 0.024). Five out of six patients with the loss of 8p11.23 died within 8 months after initial diagnosis with a median survival of 6 months. Several candidate genes were identified in the regions with frequent chromosomal aberrations, including ADAM3A (8p11.23) and GSTT1 (22q11.23). In summary, our studies detected recurrent genetic alterations in NK/T-cell lymphoma, some of which are associated with adverse prognosis. Some candidate genes in these regions may be involved in the pathogenesis and disease progression.

语种: 英语
所属项目编号: 30872922
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000339003700004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58615
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
2.Beijing Childrens Hosp, Dept Dermatol, Beijing 100045, Peoples R China

Recommended Citation:
Sun, Lin,Li, Min,Huang, Xin,et al. High-resolution genome-wide analysis identified recurrent genetic alterations in NK/T-cell lymphoma, nasal type, which are associated with disease progression[J]. MEDICAL ONCOLOGY,2014,31(7).
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