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学科主题临床医学
Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
Qiao, Jie1; Feng, Huai L.2
关键词polycystic ovary syndrome oocyte fertilization embryo IVF
刊名HUMAN REPRODUCTION UPDATE
2011
DOI10.1093/humupd/dmq032
17期:1页:17-33
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
资助者National Outstanding Young Scientist Grant, China ; Ferring Pharmaceuticals, NJ, USA ; National Outstanding Young Scientist Grant, China ; Ferring Pharmaceuticals, NJ, USA
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]IN-VITRO-FERTILIZATION ; EPIDERMAL-GROWTH-FACTOR ; ANTI-MULLERIAN HORMONE ; FOLLICLE-STIMULATING-HORMONE ; LEUKEMIA INHIBITORY FACTOR ; NECROSIS-FACTOR-ALPHA ; HUMAN PREOVULATORY FOLLICLES ; LUTEINIZED GRANULOSA-CELLS ; ASSISTED REPRODUCTIVE TECHNOLOGY ; CORTICOTROPIN-RELEASING HORMONE
英文摘要

background: Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and heterogeneous endocrine disorder in women of reproductive age. Although patients with PCOS are typically characterized by increased numbers of oocytes retrieved during IVF, they are often of poor quality, leading to lower fertilization, cleavage and implantation rates, and a higher miscarriage rate.

methods: For this review, we searched the database MEDLINE (1950 to January 2010) and Google for all full texts and/or abstract articles published in English with content related to oocyte maturation and embryo developmental competence.

results: The search showed that alteration of many factors may directly or indirectly impair the competence of maturating oocytes through endocrine and local paracrine/autocrine actions, resulting in a lower pregnancy rate in patients with PCOS. The extra-ovarian factors identified included gonadotrophins, hyperandrogenemia and hyperinsulinemia, although intra-ovarian factors included members of the epidermal, fibroblast, insulin-like and neurotrophin families of growth factors, as well as the cytokines.

conclusions: Any abnormality in the extra- and/or intra-ovarian factors may negatively affect the granulosa cell-oocyte interaction, oocyte maturation and potential embryonic developmental competence, contributing to unsuccessful outcomes for patients with PCOS who are undergoing assisted reproduction.

语种英语
所属项目编号30825038 ; GRTR-156
资助者National Outstanding Young Scientist Grant, China ; Ferring Pharmaceuticals, NJ, USA ; National Outstanding Young Scientist Grant, China ; Ferring Pharmaceuticals, NJ, USA
WOS记录号WOS:000285415400003
Citation statistics
Cited Times:117[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58616
Collection北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
2.NYU, Sch Med, N Shore Univ Hosp, Dept Obstet & Gynecol, Manhasset, NY 11030 USA
Recommended Citation
GB/T 7714
Qiao, Jie,Feng, Huai L.. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence[J]. HUMAN REPRODUCTION UPDATE,2011,17(1):17-33.
APA Qiao, Jie,&Feng, Huai L..(2011).Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence.HUMAN REPRODUCTION UPDATE,17(1),17-33.
MLA Qiao, Jie,et al."Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence".HUMAN REPRODUCTION UPDATE 17.1(2011):17-33.
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