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学科主题: 临床医学
题名:
Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
作者: Qiao, Jie1; Feng, Huai L.2
关键词: polycystic ovary syndrome ; oocyte ; fertilization ; embryo ; IVF
刊名: HUMAN REPRODUCTION UPDATE
发表日期: 2011
DOI: 10.1093/humupd/dmq032
卷: 17, 期:1, 页:17-33
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: IN-VITRO-FERTILIZATION ; EPIDERMAL-GROWTH-FACTOR ; ANTI-MULLERIAN HORMONE ; FOLLICLE-STIMULATING-HORMONE ; LEUKEMIA INHIBITORY FACTOR ; NECROSIS-FACTOR-ALPHA ; HUMAN PREOVULATORY FOLLICLES ; LUTEINIZED GRANULOSA-CELLS ; ASSISTED REPRODUCTIVE TECHNOLOGY ; CORTICOTROPIN-RELEASING HORMONE
英文摘要:

background: Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and heterogeneous endocrine disorder in women of reproductive age. Although patients with PCOS are typically characterized by increased numbers of oocytes retrieved during IVF, they are often of poor quality, leading to lower fertilization, cleavage and implantation rates, and a higher miscarriage rate.

methods: For this review, we searched the database MEDLINE (1950 to January 2010) and Google for all full texts and/or abstract articles published in English with content related to oocyte maturation and embryo developmental competence.

results: The search showed that alteration of many factors may directly or indirectly impair the competence of maturating oocytes through endocrine and local paracrine/autocrine actions, resulting in a lower pregnancy rate in patients with PCOS. The extra-ovarian factors identified included gonadotrophins, hyperandrogenemia and hyperinsulinemia, although intra-ovarian factors included members of the epidermal, fibroblast, insulin-like and neurotrophin families of growth factors, as well as the cytokines.

conclusions: Any abnormality in the extra- and/or intra-ovarian factors may negatively affect the granulosa cell-oocyte interaction, oocyte maturation and potential embryonic developmental competence, contributing to unsuccessful outcomes for patients with PCOS who are undergoing assisted reproduction.

语种: 英语
所属项目编号: 30825038 ; GRTR-156
项目资助者: National Outstanding Young Scientist Grant, China ; Ferring Pharmaceuticals, NJ, USA
WOS记录号: WOS:000285415400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58616
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
2.NYU, Sch Med, N Shore Univ Hosp, Dept Obstet & Gynecol, Manhasset, NY 11030 USA

Recommended Citation:
Qiao, Jie,Feng, Huai L.. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence[J]. HUMAN REPRODUCTION UPDATE,2011,17(1):17-33.
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