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学科主题: 临床医学
题名:
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis
作者: Zuo, Xianbo1,2,3,4,5,6,7,8; Sun, Liangdan1,2,3,4,5,6,7,8; Yin, Xianyong1,2,3,4,5,6,7,8; Gao, Jinping1,2,5,6,7,8; Sheng, Yujun1,2,5,6,7,8; Xu, Jinhua3,5; Zhang, Jianzhong9; He, Chundi10; Qiu, Ying11; Wen, Guangdong9; Tian, Hongqing12; Zheng, Xiaodong1,2,5,6,7,8; Liu, Shengxiu1,2,5,6,7,8; Wang, Wenjun1,2,5,6,7,8; Li, Weiran1,2,5,6,7,8; Cheng, Yuyan1,2,5,6,7,8; Liu, Longdan1,2,5,6,7,8; Chang, Yan1,2,5,6,7,8; Wang, Zaixing1,2,5,6,7,8; Li, Zenggang1,2,5,6,7,8; Li, Longnian1,2,5,6,7,8; Wu, Jianping1,2,5,6,7,8; Fang, Ling1,2,5,6,7,8; Shen, Changbing1,2,5,6,7,8; Zhou, Fusheng1,2,5,6,7,8; Liang, Bo1,2,5,6,7,8; Chen, Gang1,2,5,6,7,8; Li, Hui1,2,5,6,7,8; Cui, Yong5,6,7,8; Xu, Aie13; Yang, Xueqin14; Hao, Fei15; Xu, Limin16; Fan, Xing1,2,5,6,7,8; Li, Yuzhen17; Wu, Rina18; Wang, Xiuli19; Liu, Xiaoming20; Zheng, Min21; Song, Shunpeng22; Ji, Bihua23; Fang, Hong24; Yu, Jianbin25; Sun, Yongxin26; Hui, Yan27; Zhang, Furen12; Yang, Rongya28; Yang, Sen1,2,5,6,7,8; Zhang, Xuejun1,2,3,4,5,6,7,8
刊名: NATURE COMMUNICATIONS
发表日期: 2015-04-01
DOI: 10.1038/ncomms7793
卷: 6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENOME-WIDE ASSOCIATION ; INFLAMMATORY-BOWEL-DISEASE ; LOW-FREQUENCY ; COMMON VARIANTS ; RARE VARIANTS ; MACULAR DEGENERATION ; NUCLEAR-ENVELOPE ; GENES ; CONTRIBUTE ; METAANALYSIS
英文摘要:

Genome-wide association studies (GWASs) have reproducibly associated similar to 40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P<5.00 x 10(-08)). In addition, we also replicate four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D-LCE3E. These susceptibility variants identified in the current study collectively account for 1.9% of the psoriasis heritability. The variant within AIM2 is predicted to impact protein structure. Our findings increase the number of genetic risk factors for psoriasis and highlight new and plausible biological pathways in psoriasis.

语种: 英语
所属项目编号: 81130031 ; 81222022 ; 81072461 ; 31000528 ; 81000692 ; 81071285 ; 81172866 ; 81172591 ; 81370044 ; 31200939 ; NCET-11-0889 ; 2012CB722404 ; 1508085JGD05 ; IRT-1046
项目资助者: Key Program of the National Natural Science Foundation of China ; National Science Fund for Excellent Young Scholars ; Outstanding Talents of Organization Department of the CPC (Communist Party of China) Central Committee program ; Local Universities Characteristics and Advantages of Discipline Development Program of the Ministry of Finance of China ; National Natural Science Foundation of China ; New Century Excellent Talents in University ; Pre-National Basic Research Program of China (973 Plan) ; Program for Outstanding Talents of Anhui Medical University ; Anhui Province Natural Science Foundation Program ; Program for Changjiang Scholars and Innovative Research Team in University
WOS记录号: WOS:000353702500033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58617
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Dermatol, Hefei 230032, Anhui, Peoples R China
2.Third Peoples Hosp Hangzhou, Hangzhou 310009, Zhejiang, Peoples R China
3.PLA Air Force, Gen Hosp, Dept Dermatol, Beijing 100036, Peoples R China
4.Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei 230022, Anhui, Peoples R China
5.Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei 230022, Anhui, Peoples R China
6.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200040, Peoples R China
7.Anhui Med Univ, Hosp 2, Dept Dermatol, Hefei 230022, Anhui, Peoples R China
8.Anhui Med Univ, Collaborat Innovat Ctr Complex & Severe Skin Dis, Hefei 230032, Anhui, Peoples R China
9.Minist Sci & Technol, State Key Lab Incubat Dermatol, Hefei 230032, Anhui, Peoples R China
10.Key Lab Gene Resources Utilizat Severe Inherited, Hefei 230032, Anhui, Peoples R China
11.Peking Univ, Dept Dermatol, Peoples Hosp, Beijing 100044, Peoples R China
12.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Liaoning, Peoples R China
13.Jining 1 Peoples Hosp, Dept Dermatol, Jining 272011, Shandong, Peoples R China
14.Shandong Prov Inst Dermatol & Venereol, Jinan 250022, Shandong, Peoples R China
15.Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing 400038, Peoples R China
16.Tianjin Changzheng Hosp, Dept Dermatol, Tianjin 300106, Peoples R China
17.Harbin Med Univ, Affiliated Hosp 2, Dept Dermatol, Harbin 150000, Heilongjiang, Peoples R China
18.Affiliated Hosp Inner Mongolia Med Coll, Dept Dermatol, Hohhot 010050, Inner Mongolia, Peoples R China
19.Shanghai Skin Dis & STD Hosp, Shanghai 200050, Peoples R China
20.Dalian Med Univ, Affiliated Hosp 1, Dept Dermatol, Dalian 116011, Liaoning, Peoples R China
21.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Dermatol, Zhenjiang 310009, Peoples R China
22.Dalian Dermatosis Hosp, Dept Dermatol, Liaoning 116011, Peoples R China
23.Wannan Med Coll, Yijishan Hosp, Dept Dermatol, Wuhu 241000, Anhui, Peoples R China
24.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Dermatol, Zhenjiang 310006, Peoples R China
25.Zhengzhou Univ, Affiliated Hosp 1, Dept Dermatol, Zhengzhou 450052, Henan, Peoples R China
26.Anshan Tanggangzi Hosp, Dept Dermatol, Liaoning 210300, Peoples R China
27.Xinjiang Med Univ, Affiliated Hosp 1, Dept Dermatol, Xinjiang 830054, Peoples R China
28.Beijing Mil Command, Gen Hosp, Dept Dermatol, Beijing 100010, Peoples R China

Recommended Citation:
Zuo, Xianbo,Sun, Liangdan,Yin, Xianyong,et al. Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis[J]. NATURE COMMUNICATIONS,2015,6.
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