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学科主题: 药学
题名:
Two diastereomeric saponins with cytotoxic activity from Albizia julibrissin
作者: Zou, K; Zhao, YY; Tu, GZ; Cui, JR; Jia, ZH; Zhang, RY
关键词: Albizia julibrissin ; julibroside J(1) ; julibroside J(9) ; diastereomer ; cytotoxity
刊名: CARBOHYDRATE RESEARCH
发表日期: 2000-02-25
卷: 324, 期:3, 页:182-188
收录类别: IC ; SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
英文摘要:

Two diastereomeric saponins, julibrosides J(1) (1) and J(9) (2), both of which show cytotoxic activity, were obtained from the stem bark of Albizia julibrissin Durazz. On the basis of chemical and spectral evidence [L.B. Ma et al., Carbohydr. Res., 281 (1996) 35-46], the structure of I was revised as 3-O-[beta-D-xylopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranosyl]21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-[4-O-(6R)-2-trans-2,6-dimethyl-6- O-(beta-D-quinovopyranosyl)-2,7-octadienoyl)-beta-Dquinovopyranosyl]-2,7-octadienoyl}acacic acid-28-O-beta-D-glucopyranosyl-(1 --> 3)-[alpha-L-arabinofuranosyl-(1 --> 4)]-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl ester. The diastereoisomer 2 of 1 was identified as 3-O-[beta-D-xylopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranosyl]-21- O-{(6S)-2- trans-2-hydroxymethyl-6-methyl-6-O-[4-O-((6S)-2-trans-2,6-dimethyl-6-O-(beta-D-quinovopyranosyl)-2,7-octadienoyl)-beta-D-quinovopyranosyl)-2,7-octadienoyl} acacic acid-28-O-beta-D-glucopyranosyl-(1 --> 3)-[alpha-L-arabinofuranosyl-(1 --> 4)]-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl ester. Saponin 2 is a new saponin named julibroside J(9). Both julibrosides J(1) and J(9) show good inhibitory action against the KB cancer cell line in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000085354000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58618
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Med Univ, Sch Pharmaceut Sci, Div Nat Med Chem, Beijing 100083, Peoples R China
2.Beijing Inst Microchem, Beijing 100091, Peoples R China
3.Toho Univ, Dept Pharmacognosy, Chiba 2748510, Japan

Recommended Citation:
Zou, K,Zhao, YY,Tu, GZ,et al. Two diastereomeric saponins with cytotoxic activity from Albizia julibrissin[J]. CARBOHYDRATE RESEARCH,2000,324(3):182-188.
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