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Two diastereomeric saponins with cytotoxic activity from Albizia julibrissin
Zou, K; Zhao, YY; Tu, GZ; Cui, JR; Jia, ZH; Zhang, RY
关键词Albizia julibrissin julibroside J(1) julibroside J(9) diastereomer cytotoxity
刊名CARBOHYDRATE RESEARCH
2000-02-25
324期:3页:182-188
收录类别IC ; SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
英文摘要

Two diastereomeric saponins, julibrosides J(1) (1) and J(9) (2), both of which show cytotoxic activity, were obtained from the stem bark of Albizia julibrissin Durazz. On the basis of chemical and spectral evidence [L.B. Ma et al., Carbohydr. Res., 281 (1996) 35-46], the structure of I was revised as 3-O-[beta-D-xylopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranosyl]21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-[4-O-(6R)-2-trans-2,6-dimethyl-6- O-(beta-D-quinovopyranosyl)-2,7-octadienoyl)-beta-Dquinovopyranosyl]-2,7-octadienoyl}acacic acid-28-O-beta-D-glucopyranosyl-(1 --> 3)-[alpha-L-arabinofuranosyl-(1 --> 4)]-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl ester. The diastereoisomer 2 of 1 was identified as 3-O-[beta-D-xylopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranosyl]-21- O-{(6S)-2- trans-2-hydroxymethyl-6-methyl-6-O-[4-O-((6S)-2-trans-2,6-dimethyl-6-O-(beta-D-quinovopyranosyl)-2,7-octadienoyl)-beta-D-quinovopyranosyl)-2,7-octadienoyl} acacic acid-28-O-beta-D-glucopyranosyl-(1 --> 3)-[alpha-L-arabinofuranosyl-(1 --> 4)]-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl ester. Saponin 2 is a new saponin named julibroside J(9). Both julibrosides J(1) and J(9) show good inhibitory action against the KB cancer cell line in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000085354000004
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被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58618
专题北京大学药学院
作者单位1.Beijing Med Univ, Sch Pharmaceut Sci, Div Nat Med Chem, Beijing 100083, Peoples R China
2.Beijing Inst Microchem, Beijing 100091, Peoples R China
3.Toho Univ, Dept Pharmacognosy, Chiba 2748510, Japan
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GB/T 7714
Zou, K,Zhao, YY,Tu, GZ,et al. Two diastereomeric saponins with cytotoxic activity from Albizia julibrissin[J]. CARBOHYDRATE RESEARCH,2000,324(3):182-188.
APA Zou, K,Zhao, YY,Tu, GZ,Cui, JR,Jia, ZH,&Zhang, RY.(2000).Two diastereomeric saponins with cytotoxic activity from Albizia julibrissin.CARBOHYDRATE RESEARCH,324(3),182-188.
MLA Zou, K,et al."Two diastereomeric saponins with cytotoxic activity from Albizia julibrissin".CARBOHYDRATE RESEARCH 324.3(2000):182-188.
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