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学科主题: 临床医学
题名:
A case-control study on risk factors of breast cancer in China
作者: Xu, Ya-Li1; Sun, Qiang1; Shan, Guang-Liang2; Zhang, Jin3; Liao, Hai-Bo4; Li, Shi-Yong5; Jiang, Jun6; Shao, Zhi-Min7; Jiang, Hong-Chuan8; Shen, Nian-Chun9; Shi, Yue; Yu, Cheng-Ze10; Zhang, Bao-Ning11; Chen, Yan-Hua12; Duan, Xue-Ning13; Li, Bo14
关键词: breast cancer ; risk factors ; case-control study
刊名: ARCHIVES OF MEDICAL SCIENCE
发表日期: 2012-04-01
DOI: 10.5114/aoms.2012.28558
卷: 8, 期:2, 页:303-309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MAMMOGRAPHIC DENSITY ; GAIL MODEL ; PREDICTION MODELS ; CLINICAL-PRACTICE ; FAMILY-HISTORY ; WOMENS HEALTH ; ABSOLUTE RISK ; TRENDS ; CHEMOPREVENTION ; OPPORTUNITIES
英文摘要:

Introduction: To screen the risk factors associated with breast cancer among Chinese women in order to evaluate the individual risk of developing breast cancer among women in China.

Material and methods: A case-control study on 416 breast cancer patients and 1156 matched controls was conducted in 14 hospitals in 8 provinces of China in 2008. Controls were age- and region-matched to the cases. Clinicians conducted in-person interviews with the subjects to collect information on demographics and suspected risk factors for breast cancer that are known worldwide. Conditional logistic regression was used to derive odds ratios (OR) and 95% confidence intervals (CI) for the associations between risk factors and breast cancer.

Results: Compared with matched controls, women with breast cancer were significantly more likely to have higher body mass index (BMI, OR = 4.07, 95% CI; 2.98-5.55), history of benign breast disease (BBD) biopsy (OR = 1.68, 95% CI; 1.19-2.38), older age of menarche (AOM) (OR = 1.41, 95% CI: 107-187), stress anticipation (SA), for grade 1-4, OR = 2.15, 95% CI; 1.26-3.66; for grade 5-9, OR = 3.48, 95% CI; 2.03-5.95) and menopause (OR = 2.22, 95% CI: 1.50-3.282) at the level of p < 0.05. Family history of breast cancer (FHBC) in first-degree relatives (OR = 1.66, 95% CI; 0.77-3.59) and use of oral contraceptives (OC) (OR = 1.59, 95% CI; 0.83-3.05) were associated with an increased risk of breast cancer at the level of p < 0.20.

Conclusions: Our results showed that BMI, history of BBD biopsy, older AOM, SA and menopause were associated with increased risk of breast cancer among Chinese women. The findings derived from the study provided some suggestions for population-based prevention and control of breast cancer in China.

语种: 英语
WOS记录号: WOS:000304232700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58623
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Tianjin Med Univ, Canc Hosp, Tianjin, Peoples R China
2.YingBin Surg Hosp Yancheng, Yancheng, Jiangsu, Peoples R China
3.Beijing Mil Area Command, Gen Hosp, Beijing, Peoples R China
4.Fudan Univ, Canc Hosp, Shanghai 200433, Peoples R China
5.Chinese 307 Hosp Peoples Liberat Army, Beijing, Peoples R China
6.Matern & Child Care Ctr Qinhuangdao, Hebei, Peoples R China
7.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
8.Beijing Hosp, Minist Hlth, Beijing, Peoples R China
9.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Breast Surg, Beijing 100730, Peoples R China
10.Chinese Acad Med Sci, Sch Basic Med, Peking Union Med Coll, Inst Basic Med Sci, Beijing 100730, Peoples R China
11.Third Mil Med Univ, Southwest Hosp, Chongqing, Peoples R China
12.Capital Med Univ, Beijing ChaoYang Hosp, Beijing, Peoples R China
13.Populat & Family Planning Serv Ctr Zhuhai, Zhuhai, Guangdong, Peoples R China
14.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Canc Inst & Hosp, Beijing 100730, Peoples R China

Recommended Citation:
Xu, Ya-Li,Sun, Qiang,Shan, Guang-Liang,et al. A case-control study on risk factors of breast cancer in China[J]. ARCHIVES OF MEDICAL SCIENCE,2012,8(2):303-309.
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