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学科主题: 临床医学
题名:
Effects of Estradiol Valerate and Remifemin on Norepinephrine Signaling in the Brain of Ovariectomized Rats
作者: Wang, Wenjuan1; Bai, Wenpei2; Cui, Guangxia2,3; Jin, Biao1; Wang, Ke1; Jia, Jing4; Da, Yunmeng4; Qin, Lihua1
关键词: Estradiol valerate ; Remifemin ; Norepinephrine pathway ; Preoptic area of the hypothalamus ; Locus coeruleus ; Ovariectomized rats
刊名: NEUROENDOCRINOLOGY
发表日期: 2015
DOI: 10.1159/000375162
卷: 101, 期:2, 页:120-132
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Neurosciences
研究领域[WOS]: Endocrinology & Metabolism ; Neurosciences & Neurology
关键词[WOS]: ESTROGEN-RECEPTOR-ALPHA ; BLACK COHOSH EXTRACT ; BODY-TEMPERATURE ; GENE-EXPRESSION ; COLD-EXPOSURE ; IN-VITRO ; NEURONS ; NORADRENALINE ; HYPOTHALAMUS ; HYDROXYLASE
英文摘要:

Aims: We investigated the norepinephrine pathway changes from the locus coeruleus (LC) to the preoptic area of the hypothalamus (POAH) in the brain of ovariectomized rats under low estrogen levels and explored the therapeutic effects of estradiol valerate (E-2) and Remifemin (ICR) on these changes. Methods: 40 female Sprague-Dawley rats were randomly divided into the following groups: surgery with vehicle (SHAM), ovariectonny surgery with vehicle (OVX), ovariectomy with E-2 treatment (OVX + E-2), and ovariectomy with Remifemin (OVX + ICR). After 4 weeks of treatment, we observed the changes by immunohistochemistry. Results: (1) The average optical density of DBH-ir fibers and the number of alpha(1)-adrenoreceptor- and estrogen receptor (ER)alpha-positive neurons in the main nuclei of POAH were all reduced in OVX rats compared with the SHAM group. The above changes were normalized in all nuclei of the POAH in the E-2 group, while they were normalized in some nuclei in the ICR group. Coexpression of ER alpha and alpha(1)-adrenoreceptor was observed in the POAH. (2) The number of DBH- and ER alpha-positive neurons in the LC decreased in the OVX group compared with the SHAM group and increased after treatment with E-2 and ICR. Coexpression of ERa and DBH was observed in the LC. Conclusion: Low estrogen (OVX) altered norepinephrine synthesis in the LC, the projection of norepinephrine fibers and alpha(1)-adrenoreceptor expression in the POAH. Both E-2 and ICR normalized the norepinephrine pathway, but E-2 achieved greater effects than ICR. ICR had different effects in different nuclei in the POAH and its therapeutic effect was better in the LC. (C) 2015 S. Karger AG, Basel

语种: 英语
所属项目编号: 81170539
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000354231100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58629
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Civil Aviat Gen Hosp, Dept Gynecol & Obstet, Beijing, Peoples R China
2.Gen Hosp Armed Police, Dept Stonnatol, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Gynecol & Obstet, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Wenjuan,Bai, Wenpei,Cui, Guangxia,et al. Effects of Estradiol Valerate and Remifemin on Norepinephrine Signaling in the Brain of Ovariectomized Rats[J]. NEUROENDOCRINOLOGY,2015,101(2):120-132.
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