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学科主题: 药学
题名:
Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?
作者: Huang, Meiling1,2; Wu, Yaling1,2; Wang, Na1,2; Wang, Ziwei1,2; Zhao, Pan1,2; Yang, Xiaoda1,2,3
关键词: bis((5-Hydroxy-4-oxo-4H-pyran-2-yl) methyl 2-hydroxy-benzoatato) oxovanadium (IV) ; Vanadium ; Diabetes ; Feeding suppression ; Peroxisome proliferator-activated receptor gamma ; c-Jun N-terminal protein kinase
刊名: BIOLOGICAL TRACE ELEMENT RESEARCH
发表日期: 2014-03-01
DOI: 10.1007/s12011-013-9882-6
卷: 157, 期:3, 页:242-248
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: INSULIN-RECEPTOR SUBSTRATE-1 ; PPAR-GAMMA ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; IN-VITRO ; VANADATE ; RESISTANCE ; INHIBITION ; PATHWAY ; JNK
英文摘要:

Vanadium compounds exhibit effective hypoglycemic activity in both type I and type II diabetes mellitus. However, there was one argument that the hypoglycemic action of vanadium compounds could be attributable to the suppression of feeding-one common toxic aspect of vanadium compounds. To clarify this question, we investigated in this work the effect of a vanadyl complex, BSOV (bis((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl-2-hydroxy-benzoatato) oxovanadium (IV)), on diabetic obese (db/db) mice at a low dose (0.05 mmol/kg/day) when BSOV did not inhibit feeding. The experimental results showed that this dose of BSOV effectively normalized the blood glucose level in diabetic mice without affecting the body weight growth. Western blotting assays on the white adipose tissue of db/db mice further indicated that BSOV treatment significantly improved expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and activated AMP-activated protein kinase (AMPK). In addition, vanadium treatment caused a significant suppression of phosphorylation of c-Jun N-terminal protein kinase (JNK), which plays a key role in insulin-resistance in type II diabetes. This is the first evidence that the mechanism of insulin enhancement action involves interaction of vanadium compounds with JNK. Overall, the present work indicated that vanadium compounds exhibit antidiabetic effects irrelevant to food intake suppression but by modulating the signal transductions of diabetes and other metabolic disorders.

语种: 英语
所属项目编号: 21271012 ; 20971008
项目资助者: NSFC ; Founder Research Fund for Drug Discovery and Innovation
WOS记录号: WOS:000331737000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58631
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Peking Univ, SATCM Key Lab Compound Drug Detoxificat, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Meiling,Wu, Yaling,Wang, Na,et al. Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2014,157(3):242-248.
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