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Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?
Huang, Meiling1,2; Wu, Yaling1,2; Wang, Na1,2; Wang, Ziwei1,2; Zhao, Pan1,2; Yang, Xiaoda1,2,3
关键词bis((5-Hydroxy-4-oxo-4H-pyran-2-yl) methyl 2-hydroxy-benzoatato) oxovanadium (IV) Vanadium Diabetes Feeding suppression Peroxisome proliferator-activated receptor gamma c-Jun N-terminal protein kinase
刊名BIOLOGICAL TRACE ELEMENT RESEARCH
2014-03-01
DOI10.1007/s12011-013-9882-6
157期:3页:242-248
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]INSULIN-RECEPTOR SUBSTRATE-1 ; PPAR-GAMMA ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; IN-VITRO ; VANADATE ; RESISTANCE ; INHIBITION ; PATHWAY ; JNK
英文摘要

Vanadium compounds exhibit effective hypoglycemic activity in both type I and type II diabetes mellitus. However, there was one argument that the hypoglycemic action of vanadium compounds could be attributable to the suppression of feeding-one common toxic aspect of vanadium compounds. To clarify this question, we investigated in this work the effect of a vanadyl complex, BSOV (bis((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl-2-hydroxy-benzoatato) oxovanadium (IV)), on diabetic obese (db/db) mice at a low dose (0.05 mmol/kg/day) when BSOV did not inhibit feeding. The experimental results showed that this dose of BSOV effectively normalized the blood glucose level in diabetic mice without affecting the body weight growth. Western blotting assays on the white adipose tissue of db/db mice further indicated that BSOV treatment significantly improved expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and activated AMP-activated protein kinase (AMPK). In addition, vanadium treatment caused a significant suppression of phosphorylation of c-Jun N-terminal protein kinase (JNK), which plays a key role in insulin-resistance in type II diabetes. This is the first evidence that the mechanism of insulin enhancement action involves interaction of vanadium compounds with JNK. Overall, the present work indicated that vanadium compounds exhibit antidiabetic effects irrelevant to food intake suppression but by modulating the signal transductions of diabetes and other metabolic disorders.

语种英语
WOS记录号WOS:000331737000008
项目编号21271012 ; 20971008
资助机构NSFC ; Founder Research Fund for Drug Discovery and Innovation
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58631
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Peking Univ, SATCM Key Lab Compound Drug Detoxificat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Huang, Meiling,Wu, Yaling,Wang, Na,et al. Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2014,157(3):242-248.
APA Huang, Meiling,Wu, Yaling,Wang, Na,Wang, Ziwei,Zhao, Pan,&Yang, Xiaoda.(2014).Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?.BIOLOGICAL TRACE ELEMENT RESEARCH,157(3),242-248.
MLA Huang, Meiling,et al."Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?".BIOLOGICAL TRACE ELEMENT RESEARCH 157.3(2014):242-248.
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