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学科主题: 基础医学
题名:
Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma
作者: Chu, Ming1,2; Xu, Lan1,2; Zhang, Ming-bo3; Chu, Zheng-yun3; Wang, Yue-dan1,2
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/263630
期: 0
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: COMPLEX CLASS-I ; INTERFERON ; INFLUENZA ; CELLS ; INHIBITION ; EXPRESSION ; INFECTION ; RESPONSES ; WOGONIN ; VITRO
英文摘要:

Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-gamma. production, but presented no effects in IFN-gamma. or IFN-gamma. receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-gamma. in human PBMC. Moreover, BA can directly induce IFN-gamma. production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-gamma. in major IFN-gamma. producing cells.

语种: 英语
所属项目编号: BMU20110254 ; J1030831/J0108
项目资助者: Leading Academic Discipline Project of Beijing Education Bureau ; fund for Fostering Talents in Basic Science of National Natural Science Foundation of China
WOS记录号: WOS:000366939300001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58632
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
3.Liaoning Univ Tradit Chinese Med, Pharm Dept, Liaoning 116600, Peoples R China

Recommended Citation:
Chu, Ming,Xu, Lan,Zhang, Ming-bo,et al. Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma[J]. BIOMED RESEARCH INTERNATIONAL,2015(0).
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