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学科主题基础医学
Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma
Chu, Ming1,2; Xu, Lan1,2; Zhang, Ming-bo3; Chu, Zheng-yun3; Wang, Yue-dan1,2
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/263630
0
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]COMPLEX CLASS-I ; INTERFERON ; INFLUENZA ; CELLS ; INHIBITION ; EXPRESSION ; INFECTION ; RESPONSES ; WOGONIN ; VITRO
英文摘要

Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-gamma. production, but presented no effects in IFN-gamma. or IFN-gamma. receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-gamma. in human PBMC. Moreover, BA can directly induce IFN-gamma. production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-gamma. in major IFN-gamma. producing cells.

语种英语
WOS记录号WOS:000366939300001
项目编号BMU20110254 ; J1030831/J0108
资助机构Leading Academic Discipline Project of Beijing Education Bureau ; fund for Fostering Talents in Basic Science of National Natural Science Foundation of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58632
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
3.Liaoning Univ Tradit Chinese Med, Pharm Dept, Liaoning 116600, Peoples R China
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GB/T 7714
Chu, Ming,Xu, Lan,Zhang, Ming-bo,et al. Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma[J]. BIOMED RESEARCH INTERNATIONAL,2015(0).
APA Chu, Ming,Xu, Lan,Zhang, Ming-bo,Chu, Zheng-yun,&Wang, Yue-dan.(2015).Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma.BIOMED RESEARCH INTERNATIONAL(0).
MLA Chu, Ming,et al."Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma".BIOMED RESEARCH INTERNATIONAL .0(2015).
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