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学科主题: 临床医学
题名:
Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population
作者: Zhang, Simin1; Xiao, Jianzhong2; Ren, Qian1; Han, Xueyao1; Tang, Yong1; Yang, Wenying2; Zhou, Xianghai1; Ji, Linong1
关键词: Serine racemase gene ; Single-nucleotide polymorphisms ; Type 2 diabetes mellitus
刊名: JOURNAL OF DIABETES INVESTIGATION
发表日期: 2014-05-01
DOI: 10.1111/jdi.12145
卷: 5, 期:3, 页:286-289
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: INSULIN-RESISTANCE ; GLUCOSE ; CELL
英文摘要:

A genome-wide association study in the Chinese Han population has identified several novel genetic variants of the serine racemase (SRR) gene in type 2 diabetes. Our purpose was to systematically evaluate the contribution of SRR variants in the Chinese Han population. rs391300 and rs4523957 in SRR were genotyped respectively in the two independent populations. A meta-analysis was used to estimate the effects of SRR in 21,305 Chinese Han individuals. Associations between single-nucleotide polymorphisms and diabetes-related phenotypes were analyzed among 2,615 newly diagnosed type 2 diabetes patients and 5,029 controls. Neither rs391300 nor rs4523957 were associated with type 2 diabetes in populations. Furthermore, meta-analysis did not confirm an association between type 2 diabetes and SRR. In the controls, rs391300-A and rs4523957-G were associated with higher 30-min plasma glucose in an oral glucose tolerance test. The present study did not confirm that SRR was associated with type 2 diabetes.

语种: 英语
所属项目编号: 2012AA02A509 ; 2011CB504000
项目资助者: China Medical Association Research Fund ; National High-technology Research and Development Program of China (863 Program) ; National Key Basic Research Program of China (973 Program)
WOS记录号: WOS:000335575500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58633
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Ctr Diabet, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
2.China Japan Friendship Hosp, Beijing, Peoples R China

Recommended Citation:
Zhang, Simin,Xiao, Jianzhong,Ren, Qian,et al. Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population[J]. JOURNAL OF DIABETES INVESTIGATION,2014,5(3):286-289.
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