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学科主题: 药学
题名:
Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells
作者: Ji, Wengang1,2; Ji, Yuzhuo1; Jin, Qingqing1; Tong, Qingxiao2; Tang, Xinjing1
刊名: ANALYST
发表日期: 2015
DOI: 10.1039/c5an00549c
卷: 140, 期:13, 页:4379-4383
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: DIFFERENT EMISSION CHANNELS ; FLUORESCENT-PROBE ; REACTIVE PROBES ; THIOL PROBE ; CYSTEINE ; HOMOCYSTEINE ; GLUTATHIONE ; CHEMOSENSORS ; ALDEHYDE ; SULFIDE
英文摘要:

A series of turn-on fluorescent probes with halogen acetyl amide at the 3-position of coumarin derivatives were synthesized. Fluorescence of these probes was efficiently quenched by heavy halogen atoms (Br and I, not Cl), which could be successfully used for selective detection of biothiols with the sensitivity of Cys > GSH > Hcy and much higher than thiol containing proteins. These represent the smallest fluorescence quenchers in designing fluorescent probes for detecting both endogenous and exogenous biothiols in living cells.

语种: 英语
所属项目编号: 2013CB933800 ; 2012CB720600 ; 2013CB834803 ; 21422201 ; 51273108
项目资助者: National Basic Research Program of China (&prime ; 973&prime ; Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000356171400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58634
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shantou Univ, Dept Chem, Guangzhou 515063, Guangdong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Ji, Wengang,Ji, Yuzhuo,Jin, Qingqing,et al. Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells[J]. ANALYST,2015,140(13):4379-4383.
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