IR@PKUHSC  > 北京大学首钢医院  > 泌尿外科
学科主题临床医学
Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling
Ma, Leilei1,2,3; Kong, Feijuan2,4; Ge, Hongwei5; Liu, Jingquan1; Gong, Fangxiao1; Xu, Liang1; Hu, Bangchuan1; Sun, Renhua1
刊名SCIENTIFIC REPORTS
2014-11-17
DOI10.1038/srep07071
4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NITRIC-OXIDE SYNTHASE ; CONSCIOUS RABBITS ; REPERFUSION INJURY ; INDUCED PROTECTION ; UP-REGULATION ; INFARCT SIZE ; 2ND WINDOW ; ISOFLURANE ; HEART ; CYCLOOXYGENASE-2
英文摘要

The aim of the current study was to determine whether ventricular hypertrophy affects the delayed isoflurane preconditioning against myocardial ischemia-reperfusion (IR) injury. Transverse aortic constriction (TAC) was performed on male Sprague-Dawley rats to induce left ventricular (LV) hypertrophy, then sham-operated or hypertrophied rat hearts were subjected to isoflurane preconditioning (2.1% v/v, 1 h). 24 h after exposure, the hearts were isolated and perfused retrogradely by the Langendorff for 30 min (equilibration) followed by 40 min of ischemia and then 120 min of reperfusion. The hemodynamics, infarct size, apoptosis, nitric oxide synthase (NOS), cyclooxygenase-2 (COX-2), Cleaved Caspase-3 and production of NO were determined. We found that the hemodynamic parameters were all markedly improved during the reperfusion period and the myocardial infarct size and apoptosis was significantly reduced by delayed isoflurane preconditioning in sham-operated rats. However, such cardiac improvement induced by delayed isoflurane preconditioning was not observed in hypertrophied hearts. The expression of iNOS, COX-2 and NO was markedly enhanced, whereas Cleaved Caspase-3 activity was inhibited by delayed isoflurane preconditioning in sham-operated rats, a phenomenon was not found in TAC-control groups pretreated with isoflurane. Our results demonstrated that ventricular hypertrophy abrogated isoflurane-induced delayed cardioprotection by alteration of iNOS/COX-2 pathway.

语种英语
WOS记录号WOS:000345298600003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58638
Collection北京大学首钢医院_泌尿外科
作者单位1.Zhejiang Prov Peoples Hosp, Dept Crit Care Med, Hangzhou, Zhejiang, Peoples R China
2.Nanjing Med Univ, Hangzhou Peoples Hosp 1, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200433, Peoples R China
4.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Endocrinol, Hangzhou 310003, Zhejiang, Peoples R China
5.Peking Univ, Shougang Hosp, Dept Urol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Ma, Leilei,Kong, Feijuan,Ge, Hongwei,et al. Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling[J]. SCIENTIFIC REPORTS,2014,4.
APA Ma, Leilei.,Kong, Feijuan.,Ge, Hongwei.,Liu, Jingquan.,Gong, Fangxiao.,...&Sun, Renhua.(2014).Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling.SCIENTIFIC REPORTS,4.
MLA Ma, Leilei,et al."Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling".SCIENTIFIC REPORTS 4(2014).
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