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Childhood Chronic Inflammatory Demyelinating Polyneuropathy With Nonuniform Pathologic Features
Luan, Xinghua; Zheng, Riliang; Chen, Bin; Yuan, Yun
刊名PEDIATRIC NEUROLOGY
2010-08-01
DOI10.1016/j.pediatrneurol.2010.04.001
43期:2页:103-109
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pediatrics
研究领域[WOS]Neurosciences & Neurology ; Pediatrics
关键词[WOS]PERIPHERAL-NERVE ; MONOCLONAL GAMMOPATHY ; CLINICAL-COURSE ; POLYRADICULONEUROPATHY ; BIOPSY ; SYSTEM ; CIDP ; INVOLVEMENT ; NEUROPATHY
英文摘要

Nonuniform pathologic changes in chronic inflammatory demyelinating polyneuropathy were previously reported only in adult humans. We analyzed the pathologic features of 12 children, aged 2-17 years, with chronic inflammatory demyelinating polyneuropathy. Six patients manifested a preceding illness. Five patients presented a chronic, monophasic course, and seven presented a relapsing-remitting course. Three patients exhibited multiple cranial-nerve involvement. Five of 12 (41.7%) patients presented nonuniform features. Two subtypes of nonuniform lesions were revealed. One exhibited varying myelinated fiber content between nerve fascicles, and one exhibited onion bulbs involving a variable number of fascicles. Macrophages were evident in 11 patients, and the number of CD3-positive T cells in the nonuniform group was greater compared with the uniform group (P = 0.045). Our results demonstrate that childhood chronic inflammatory demyelinating polyneuropathy exhibits pathologically nonuniform features, thus providing more evidence to assist in differential diagnoses of pediatric patients. However, clinical and electrophysiologic features, as well as responses to treatment, were similar in the nonuniform and uniform groups. (C) 2010 by Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000280032600005
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58641
专题北京大学第一临床医学院_神经内科
北京大学第二临床医学院_血液科
作者单位Peking Univ, Neuropathol Lab, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Luan, Xinghua,Zheng, Riliang,Chen, Bin,et al. Childhood Chronic Inflammatory Demyelinating Polyneuropathy With Nonuniform Pathologic Features[J]. PEDIATRIC NEUROLOGY,2010,43(2):103-109.
APA Luan, Xinghua,Zheng, Riliang,Chen, Bin,&Yuan, Yun.(2010).Childhood Chronic Inflammatory Demyelinating Polyneuropathy With Nonuniform Pathologic Features.PEDIATRIC NEUROLOGY,43(2),103-109.
MLA Luan, Xinghua,et al."Childhood Chronic Inflammatory Demyelinating Polyneuropathy With Nonuniform Pathologic Features".PEDIATRIC NEUROLOGY 43.2(2010):103-109.
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