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学科主题: 临床医学
题名:
Childhood Chronic Inflammatory Demyelinating Polyneuropathy With Nonuniform Pathologic Features
作者: Luan, Xinghua; Zheng, Riliang; Chen, Bin; Yuan, Yun
刊名: PEDIATRIC NEUROLOGY
发表日期: 2010-08-01
DOI: 10.1016/j.pediatrneurol.2010.04.001
卷: 43, 期:2, 页:103-109
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Pediatrics
研究领域[WOS]: Neurosciences & Neurology ; Pediatrics
关键词[WOS]: PERIPHERAL-NERVE ; MONOCLONAL GAMMOPATHY ; CLINICAL-COURSE ; POLYRADICULONEUROPATHY ; BIOPSY ; SYSTEM ; CIDP ; INVOLVEMENT ; NEUROPATHY
英文摘要:

Nonuniform pathologic changes in chronic inflammatory demyelinating polyneuropathy were previously reported only in adult humans. We analyzed the pathologic features of 12 children, aged 2-17 years, with chronic inflammatory demyelinating polyneuropathy. Six patients manifested a preceding illness. Five patients presented a chronic, monophasic course, and seven presented a relapsing-remitting course. Three patients exhibited multiple cranial-nerve involvement. Five of 12 (41.7%) patients presented nonuniform features. Two subtypes of nonuniform lesions were revealed. One exhibited varying myelinated fiber content between nerve fascicles, and one exhibited onion bulbs involving a variable number of fascicles. Macrophages were evident in 11 patients, and the number of CD3-positive T cells in the nonuniform group was greater compared with the uniform group (P = 0.045). Our results demonstrate that childhood chronic inflammatory demyelinating polyneuropathy exhibits pathologically nonuniform features, thus providing more evidence to assist in differential diagnoses of pediatric patients. However, clinical and electrophysiologic features, as well as responses to treatment, were similar in the nonuniform and uniform groups. (C) 2010 by Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000280032600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58641
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Neuropathol Lab, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Luan, Xinghua,Zheng, Riliang,Chen, Bin,et al. Childhood Chronic Inflammatory Demyelinating Polyneuropathy With Nonuniform Pathologic Features[J]. PEDIATRIC NEUROLOGY,2010,43(2):103-109.
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