北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment
作者: Luo, Jian-Quan1; Wang, Lu-Yan2; He, Fa-Zhong1; Sun, Ning-Ling2; Tang, Gen-Fu3; Wen, Jia-Gen1; Luo, Zhi-Ying1; Liu, Zhao-Qian1; Zhou, Hong-Hao1; Chen, Xiao-Ping1; Zhang, Wei1
关键词: antihypertensive response ; enalapril ; NR3C2 ; single nucleotide polymorphism ; SNP
刊名: PHARMACOGENOMICS
发表日期: 2014-02-01
DOI: 10.2217/pgs.13.173
卷: 15, 期:2, 页:201-208
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CORONARY-ARTERY-DISEASE ; MINERALOCORTICOID RECEPTOR MUTATIONS ; CONVERTING ENZYME-INHIBITORS ; PSEUDOHYPOALDOSTERONISM TYPE-1 ; MYOCARDIAL-INFARCTION ; HYPERTENSION ; ASSOCIATION ; PERINDOPRIL ; EXPRESSION ; THERAPY
英文摘要:

Aim: The mineralocorticoid receptor (MR; also known as NR3C2) plays important roles in the modulation of blood pressure. The effect of NR3C2 polymorphisms on antihypertensive response to enalapril was investigated. Patients & methods: Two hundred and seventy nine essential hypertension patients treated with enalapril were genotyped for two NR3C2 tagSNPs, rs5522 and rs2070950, by Sequenom MassArray technology. Results: The reductions in diastolic blood pressure (DBP) were significantly greater in AA homozygotes compared with AG+GG genotype carriers for the rs5522 polymorphism (p = 0.009), and the reductions in DBP were greater in GG homozygotes compared with GC+CC genotype carriers for the rs2070950 polymorphism, with marginal significance (p = 0.065). Stepwise multiple regression analysis indicated that significant predictors of DBP reduction were baseline DBP (p < 0.001), waist:hip ratio (p = 0.001) and rs5522 genotype (p = 0.003). Conclusion:NR3C2 rs5522 affects blood pressure response to enalapril treatment and may serve as a useful pharmacogenomic marker of antihypertensive response to enalapril in essential hypertension patients. Original submitted 8 August 2013; Revision submitted 29 August 2013; Published online 23 September 2013

语种: 英语
所属项目编号: 81273595 ; 81202594 ; 81001445 ; 2012AA02A517 ; 2012AA02A518 ; 11K073 ; 10JJ4020
项目资助者: National Scientific Foundation of China ; "863&prime ; Project ; Scientific Foundation of Hunan
WOS记录号: WOS:000331062200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58646
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Anhui Med Univ, Sch Hlth Adm, Hefei 230032, Peoples R China
2.Cent S Univ, Pharmacogenet Res Inst, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Luo, Jian-Quan,Wang, Lu-Yan,He, Fa-Zhong,et al. Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment[J]. PHARMACOGENOMICS,2014,15(2):201-208.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Luo, Jian-Quan]'s Articles
[Wang, Lu-Yan]'s Articles
[He, Fa-Zhong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Luo, Jian-Quan]‘s Articles
[Wang, Lu-Yan]‘s Articles
[He, Fa-Zhong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace