IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment
Luo, Jian-Quan1; Wang, Lu-Yan2; He, Fa-Zhong1; Sun, Ning-Ling2; Tang, Gen-Fu3; Wen, Jia-Gen1; Luo, Zhi-Ying1; Liu, Zhao-Qian1; Zhou, Hong-Hao1; Chen, Xiao-Ping1; Zhang, Wei1
关键词antihypertensive response enalapril NR3C2 single nucleotide polymorphism SNP
刊名PHARMACOGENOMICS
2014-02-01
DOI10.2217/pgs.13.173
15期:2页:201-208
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CORONARY-ARTERY-DISEASE ; MINERALOCORTICOID RECEPTOR MUTATIONS ; CONVERTING ENZYME-INHIBITORS ; PSEUDOHYPOALDOSTERONISM TYPE-1 ; MYOCARDIAL-INFARCTION ; HYPERTENSION ; ASSOCIATION ; PERINDOPRIL ; EXPRESSION ; THERAPY
英文摘要

Aim: The mineralocorticoid receptor (MR; also known as NR3C2) plays important roles in the modulation of blood pressure. The effect of NR3C2 polymorphisms on antihypertensive response to enalapril was investigated. Patients & methods: Two hundred and seventy nine essential hypertension patients treated with enalapril were genotyped for two NR3C2 tagSNPs, rs5522 and rs2070950, by Sequenom MassArray technology. Results: The reductions in diastolic blood pressure (DBP) were significantly greater in AA homozygotes compared with AG+GG genotype carriers for the rs5522 polymorphism (p = 0.009), and the reductions in DBP were greater in GG homozygotes compared with GC+CC genotype carriers for the rs2070950 polymorphism, with marginal significance (p = 0.065). Stepwise multiple regression analysis indicated that significant predictors of DBP reduction were baseline DBP (p < 0.001), waist:hip ratio (p = 0.001) and rs5522 genotype (p = 0.003). Conclusion:NR3C2 rs5522 affects blood pressure response to enalapril treatment and may serve as a useful pharmacogenomic marker of antihypertensive response to enalapril in essential hypertension patients. Original submitted 8 August 2013; Revision submitted 29 August 2013; Published online 23 September 2013

语种英语
WOS记录号WOS:000331062200013
项目编号81273595 ; 81202594 ; 81001445 ; 2012AA02A517 ; 2012AA02A518 ; 11K073 ; 10JJ4020
资助机构National Scientific Foundation of China ; "863&prime ; Project ; Scientific Foundation of Hunan
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58646
专题北京大学第二临床医学院_心血管内科
作者单位1.Anhui Med Univ, Sch Hlth Adm, Hefei 230032, Peoples R China
2.Cent S Univ, Pharmacogenet Res Inst, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Luo, Jian-Quan,Wang, Lu-Yan,He, Fa-Zhong,et al. Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment[J]. PHARMACOGENOMICS,2014,15(2):201-208.
APA Luo, Jian-Quan.,Wang, Lu-Yan.,He, Fa-Zhong.,Sun, Ning-Ling.,Tang, Gen-Fu.,...&Zhang, Wei.(2014).Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment.PHARMACOGENOMICS,15(2),201-208.
MLA Luo, Jian-Quan,et al."Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment".PHARMACOGENOMICS 15.2(2014):201-208.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Luo, Jian-Quan]的文章
[Wang, Lu-Yan]的文章
[He, Fa-Zhong]的文章
百度学术
百度学术中相似的文章
[Luo, Jian-Quan]的文章
[Wang, Lu-Yan]的文章
[He, Fa-Zhong]的文章
必应学术
必应学术中相似的文章
[Luo, Jian-Quan]的文章
[Wang, Lu-Yan]的文章
[He, Fa-Zhong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。