北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A
作者: Dai, Wenbing; Guo, Yulan; Zhang, Hua; Wang, Xueqing; Zhang, Qiang
关键词: Bioavailability ; Cyclosporine A ; Poorly soluble drug ; pH-sensitive delivery system ; Nanomatrix
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2015-01-30
DOI: 10.1016/j.ijpharm.2014.11.030
卷: 478, 期:2, 页:718-725
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PH-SENSITIVE NANOPARTICLES ; POORLY SOLUBLE DRUGS ; SILICA NANOPARTICLES ; IMPROVED DISSOLUTION ; LIPID NANOPARTICLES ; BIOAVAILABILITY ; DISPERSION ; PHARMACOKINETICS ; INCLUSION ; RELEASE
英文摘要:

Cyclosporine A (CyA) is a poorly soluble peptide and the available preparation is the surfactant based Sandimmum Neoral (R). In this study, we developed a novel pH-sensitive nanomatrix system of CyA with medical-grade nanoporous silica and Eudragit to enhance the oral absorption of CyA as well as to improve the potential nephrotoxicity caused by the pronounced initial plasma peak of Neoral (R). The nanomatrixs were prepared by an absolutely simple conventional process. The scanning electron microscopy (SEM), X-ray powder diffraction analysis (XRD), differential thermal analysis (DSC) and specific surface area and pore size analysis were used to analyze the physicochemical characterization of the nanomatrix. The nanomatrix, consisted of CyA, Eudragit (R) S100 and Sylysia 350(1/5/5, w/w/w %), not only increased the dissolution of CyA in vitro but also exhibited excellent enteric behavior. The characterization of CyA nanomatrix showed the CyA was highly dispersed in the nanomatrix in a molecular or amorphous state and partly filled into the nanopores of Sylysia 350. The results of comparative pharmacokinetic study showed that the optimized nanomatrix had a relative bioavailability of 90.8% with Neoral (R) but a lower C-max than that of Neoral (R). In conclusion, the novel nanomatrix of CyA, composed of pharmaceutical excipients of biological safety and easily prepared, is expected to become a promising marketed product for the oral delivery of CyA. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2014ZX09507001-008 ; 2015CB932100
项目资助者: Ministry of Science and Technology ; National Basic Research Program of China
WOS记录号: WOS:000349723300030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58647
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Dai, Wenbing,Guo, Yulan,Zhang, Hua,et al. Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2015,478(2):718-725.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dai, Wenbing]'s Articles
[Guo, Yulan]'s Articles
[Zhang, Hua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dai, Wenbing]‘s Articles
[Guo, Yulan]‘s Articles
[Zhang, Hua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace