IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Effect of Treadmill Running on Apelin and APJ Expression in Adipose Tissue and Skeletal Muscle in Rats Fed a High-fat Diet
Yang, H.1; Zhao, L.2; Zhang, J.2; Tang, C. -S.2; Qi, Y. -F.2; Zhang, J.1
关键词apelin APJ treadmill running insulin resistance skeletal muscle adipose tissue
刊名INTERNATIONAL JOURNAL OF SPORTS MEDICINE
2015-06-01
DOI10.1055/s-0034-1398653
36期:7页:535-541
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Sport Sciences
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Sport Sciences
关键词[WOS]INSULIN-RESISTANT MICE ; AEROBIC EXERCISE ; RECEPTOR ; OBESE ; BIOGENESIS ; SYSTEM
英文摘要

Apelin, an adipokine and also a myokine, is involved in glucose homeostasis. In this study we investigated the effect of insulin resistance and exercise on the regulation of apelin and APJ in adipose tissue and skeletal muscle. After 20 weeks of a high-fat diet (HFD), rats showed severe insulin resistance, with increased fasting blood sugar and plasma insulin and impaired glucose tolerance. Plasma apelin immunoreactivity as well as apelin and APJ expression in adipose tissue and gastrocnemius muscle were significantly increased, with no difference in soleus muscle. Treadmill running completely ameliorated the HFD-induced insulin resistance, decreased plasma apelin level, and downregulated apelin and APJ expression in adipose tissue. However, apelin and APJ expression was upregulated in soleus and gastrocnemius muscle with treadmill training and a HFD. Exercise had a tissue-dependent effect on apelin and APJ expression in rats fed a HFD.

语种英语
所属项目编号31471137 ; 81270921
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000356434100003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58649
专题北京大学基础医学院_心血管所
作者单位1.Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, H.,Zhao, L.,Zhang, J.,et al. Effect of Treadmill Running on Apelin and APJ Expression in Adipose Tissue and Skeletal Muscle in Rats Fed a High-fat Diet[J]. INTERNATIONAL JOURNAL OF SPORTS MEDICINE,2015,36(7):535-541.
APA Yang, H.,Zhao, L.,Zhang, J.,Tang, C. -S.,Qi, Y. -F.,&Zhang, J..(2015).Effect of Treadmill Running on Apelin and APJ Expression in Adipose Tissue and Skeletal Muscle in Rats Fed a High-fat Diet.INTERNATIONAL JOURNAL OF SPORTS MEDICINE,36(7),535-541.
MLA Yang, H.,et al."Effect of Treadmill Running on Apelin and APJ Expression in Adipose Tissue and Skeletal Muscle in Rats Fed a High-fat Diet".INTERNATIONAL JOURNAL OF SPORTS MEDICINE 36.7(2015):535-541.
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