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学科主题: 基础医学
题名:
Fetal human neural progenitors can be the target for tumor transformation
作者: Wang, YJ; Bai, Y; Li, XX; Hu, QK; Lin, CS; Xiao, ZF; Liu, YN; Xu, JC; Shen, L; Li, LS
关键词: hNPCs ; hTERT ; mutation ; neoplasia ; transformation
刊名: NEUROREPORT
发表日期: 2004-08-26
卷: 15, 期:12, 页:1907-1912
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: STEM-CELLS ; BRAIN-TUMORS ; CANCER-CELLS ; LEUKEMIA ; IDENTIFICATION ; PROLIFERATION ; ACTIVATION ; ASTROCYTES ; MECHANISM ; MICE
英文摘要:

The hypothesis that stem cells may seed cancer has emerged from the cancer stem cells concept. However, the experimental systems necessary to provide more direct evidence to support the hypothesis have been lacking. We have used fetal neural progenitor cells (hNPC) transduced with the telomerase hTERT gene to investigate the neoplastic potential of hNPCs. The hTERT-transduced line, hNPCs-G3 lost normal diploid karyotype, showed loss of contact inhibition, anchorage independence, and formed neuroblastoma-like tumours in all of 10 mice. These data suggest that hNPCs have the potential for neoplastic transformation. These data have implications for providing a novel tool to test the feasibility of new anticancer treatment strategies and raise the possibility of a risk for the use of hNPCs in cell transplantation.

语种: 英语
WOS记录号: WOS:000225141000015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58650
Appears in Collections:基础医学院_北京大学干细胞研究中心_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Wang, YJ,Bai, Y,Li, XX,et al. Fetal human neural progenitors can be the target for tumor transformation[J]. NEUROREPORT,2004,15(12):1907-1912.
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