IR@PKUHSC  > 基础医学院  > 北京大学干细胞研究中心
学科主题基础医学
Fetal human neural progenitors can be the target for tumor transformation
Wang, YJ; Bai, Y; Li, XX; Hu, QK; Lin, CS; Xiao, ZF; Liu, YN; Xu, JC; Shen, L; Li, LS
关键词hNPCs hTERT mutation neoplasia transformation
刊名NEUROREPORT
2004-08-26
15期:12页:1907-1912
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]STEM-CELLS ; BRAIN-TUMORS ; CANCER-CELLS ; LEUKEMIA ; IDENTIFICATION ; PROLIFERATION ; ACTIVATION ; ASTROCYTES ; MECHANISM ; MICE
英文摘要

The hypothesis that stem cells may seed cancer has emerged from the cancer stem cells concept. However, the experimental systems necessary to provide more direct evidence to support the hypothesis have been lacking. We have used fetal neural progenitor cells (hNPC) transduced with the telomerase hTERT gene to investigate the neoplastic potential of hNPCs. The hTERT-transduced line, hNPCs-G3 lost normal diploid karyotype, showed loss of contact inhibition, anchorage independence, and formed neuroblastoma-like tumours in all of 10 mice. These data suggest that hNPCs have the potential for neoplastic transformation. These data have implications for providing a novel tool to test the feasibility of new anticancer treatment strategies and raise the possibility of a risk for the use of hNPCs in cell transplantation.

语种英语
WOS记录号WOS:000225141000015
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58650
专题基础医学院_北京大学干细胞研究中心
作者单位Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Wang, YJ,Bai, Y,Li, XX,et al. Fetal human neural progenitors can be the target for tumor transformation[J]. NEUROREPORT,2004,15(12):1907-1912.
APA Wang, YJ.,Bai, Y.,Li, XX.,Hu, QK.,Lin, CS.,...&Li, LS.(2004).Fetal human neural progenitors can be the target for tumor transformation.NEUROREPORT,15(12),1907-1912.
MLA Wang, YJ,et al."Fetal human neural progenitors can be the target for tumor transformation".NEUROREPORT 15.12(2004):1907-1912.
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