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学科主题: 临床医学
题名:
miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas
作者: Dong, Ying1,2; Si, Jing-Wen1; Li, Wen-Ting2; Liang, Li1; Zhao, Jian3; Zhou, Mei2; Li, Dong1; Li, Ting1
关键词: Endometrial carcinoma ; miR-200a/miR-141 ; miR-205 ; ER ; PR
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2015
卷: 8, 期:3, 页:2864-2875
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: SEROUS ADENOCARCINOMAS ; BREAST-CANCER ; EXPRESSION ; MICRORNAS ; TUMOR ; PROFILES ; FAMILY ; CELLS
英文摘要:

The aim of this study was to compare the clinicopathological significance of miR-200a/miR-141 and miR-205 expression in endometrioid carcinomas (ECs) versus nonendometrioid carcinomas (NECs) and to assess their correlation with hormone receptor status. miR-200a/miR-141 and miR-205 expression in 154 endometrial cancers was determined by qRT-PCR. The status of estrogen and progesterone receptor (ER/PR) was assessed using immunohistochemistry. miR-200a/miR-141 and miR-205 increased significantly in ECs and in NECs. The expression level of miR-200a was significantly higher in NECs than in ECs (P = 0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher miR-200a expression, while an inverse trend existed in ECs. miR-205 upregulation occurred frequently in NECs without lymph node metastases (P = 0.030), whereas such association was not present in ECs. Interestingly, In ECs, miR-200a/miR-141 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P < 0.05). Similarly, the expression level of miR-205 was higher in the hormone receptor positive subgroups and the association between miR-205 and PR reached statistical significance (P = 0.024). In contrast, in NECs, a negative correlation was found between miR-200a/miR-141 and ER or PR status. Meanwhile, in ECs, miR-200a upregulation correlated with prolonged survival in the ER positive subgroup (P = 0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that miR-200a/miR-141 and miR-205 increased significantly in ECs and in NECs. However, they might behave differently in ECs versus NECs. miR-200a/miR-141 and miR-205 might be associated with hormone receptor status in endometrial cancer and may possess prognostic impacts.

语种: 英语
所属项目编号: 81360381
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000355312200062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58657
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China
2.Xinjiang Med Univ, Canc Hosp, Dept Pathol, Urumqi, Xinjiang Uygur, Peoples R China
3.Peking Univ, Hosp 1, Dept Gynecol & Obstet, Beijing 100034, Peoples R China

Recommended Citation:
Dong, Ying,Si, Jing-Wen,Li, Wen-Ting,et al. miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(3):2864-2875.
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