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学科主题: 临床医学
题名:
Evaluation of the Impact of Passive Smoke on Arterial Elasticity via Echo-Tracking Technology in a Rabbit Model
作者: Yong Qiang1; Guo Ruijun2; Chen Zhen3; Li Zhian1; Lin Changyan4; Yang Xiaohui5; Liu Shu6; Lin Jie6; Meng Yuanfeng7; Zhang Ruobing8; Cao Yan8; Ma Qiao9; Zhang Shuang1; Zhu, Yuping1
关键词: abdominal aorta ; arterial elasticity ; arterial injury ; echo-tracking technology ; New Zealand White rabbits ; sonography ; vascular ultrasound
刊名: JOURNAL OF ULTRASOUND IN MEDICINE
发表日期: 2014-11-01
DOI: 10.7863/ultra.33.11.1949
卷: 33, 期:11, 页:1949-1956
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: ENDOTHELIUM-DEPENDENT RELAXATION ; INTIMA-MEDIA THICKNESS ; L-ARGININE ; STIFFNESS ; DISEASE ; DYSFUNCTION ; CESSATION ; YOUNG ; RISK
英文摘要:

Objectives The purpose of this study was to evaluate the elasticity of the abdominal aorta in passively smoking rabbits using echo-tracking technology and pathologic examination.

Methods Fifty-four male New Zealand White rabbits were randomly divided into a passive smoking group and a normal control group. The elasticity indicators for the abdominal aorta of the rabbits were measured by means of echo tracking, which was performed before and 1, 2, and 3 months after passive smoking. Measured indicators included the pressure-strain elastic modulus, stiffness, arterial compliance, augmentation index, and pulse wave velocity. After the completion of the in vivo measurements, rabbits were euthanized randomly, and the corresponding arterial sites were resected for pathologic examination and in vitro measurement of vascular elasticity.

Results The echo-tracking technology used in our research proved that the elastic modulus, stiffness, and pulse wave velocity gradually increased with time by passive smoking, whereas arterial compliance decreased by passive smoking. Pathologic examination and in vitro measurements were performed and further confirmed the observed in vivo results.

Conclusions Passive smoking can injure arteries and reduce arterial elasticity. Echo-tracking technology is an accurate, noninvasive, and reliable method for analysis of the impact of passive smoking on arterial elasticity and detection arterial injury, which also can provide a new instructional basis for prevention and treatment of several arterial diseases.

语种: 英语
所属项目编号: ShouFa2011-2006-02 ; 7112045
项目资助者: Capital Health Research and Development of Special ; Beijing Natural Science Foundation
WOS记录号: WOS:000343794400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58659
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Capital Med Univ, Dept Ultrasound Diag, Beijing Anzhen Hosp, Beijing 100029, Peoples R China
2.Capital Med Univ, Dept Ultrasound Diag, Beijing Chaoyang Hosp, Beijing 100029, Peoples R China
3.Beijing Haidian Hosp, Dept Ultrasound Diag, Beijing, Peoples R China
4.Beijing Inst Cardiopulm Vasc Dis, Biomed Engn Res Ctr, Beijing, Peoples R China
5.Cardiovasc Dis Control & Prevent Off, Beijing, Peoples R China
6.Capital Univ Med Sci, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Res Dept Arteriosclerosis, Beijing, Peoples R China
7.Peking Univ, Dept Ultrasound Diag, Affiliated Hosp 1, Beijing 100871, Peoples R China
8.Capital Med Univ, Beijing, Peoples R China
9.Huilongguan Community Hlth Serv Ctr, Funct Dept, Beijing, Peoples R China

Recommended Citation:
Yong Qiang,Guo Ruijun,Chen Zhen,et al. Evaluation of the Impact of Passive Smoke on Arterial Elasticity via Echo-Tracking Technology in a Rabbit Model[J]. JOURNAL OF ULTRASOUND IN MEDICINE,2014,33(11):1949-1956.
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