北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study
作者: Hu, Dongzhi1; Du, Changzheng2; Xue, Weicheng3; Dou, Fangyuan3; Yao, Yunfeng2; Gu, Jin2
关键词: chemokine ; colorectal cancer ; immunohistochemistry ; metastasis ; surgery
刊名: HISTOPATHOLOGY
发表日期: 2013-08-01
DOI: 10.1111/his.12127
卷: 63, 期:2, 页:167-173
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: LYMPH-NODE METASTASIS ; COLON-CARCINOMA ; INFLAMMATION ; INHIBITION ; CCL20 ; LIVER ; RISK
英文摘要:

AimsThe liver and lung are the organs most commonly affected by metastasis in colorectal cancer (CRC), and the interaction of chemokines and chemokine receptors (CKRs) plays an important role in the metastatic process. The aim of this study was to investigate the organ specificity of CKRs in CRC distant metastasis.

Methods and resultsSurgical specimens of primary tumours from 46 patients with metachronous distant metastases were retrieved retrospectively (20 lung metastases; 26 liver metastases). As a control, the records of 29 patients without distant metastases were randomly retrieved from our database, and their specimens were reassessed. The expression rates of CKRs, including CCR6, CXCR2, and CXCR4, were determined by immunohistochemistry, and were compared among the groups. The expression rates of CCR6 and CXCR2 were both significantly higher in the metastasis group than in the non-metastasis group (P<0.05), but there was no statistical difference between the lung metastasis and liver metastasis subgroups. The expression of CXCR4 was not significantly different between the metastasis and non-metastasis groups. Multivariable analysis suggested that preoperative serum carcinoembryonic antigen level, CCR6 and CXCR2 were independent factors associated with distant metastasis.

ConclusionsThe expression of CCR6 and CXCR2 in CRC could predict metachronous distant metastasis, but they have no organ specificity for metastasis.

语种: 英语
WOS记录号: WOS:000329278300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58660
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
2.Peking Univ, Canc Hosp, Dept Colorectal Surg, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China

Recommended Citation:
Hu, Dongzhi,Du, Changzheng,Xue, Weicheng,et al. The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study[J]. HISTOPATHOLOGY,2013,63(2):167-173.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hu, Dongzhi]'s Articles
[Du, Changzheng]'s Articles
[Xue, Weicheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hu, Dongzhi]‘s Articles
[Du, Changzheng]‘s Articles
[Xue, Weicheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace