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The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study
Hu, Dongzhi1; Du, Changzheng2; Xue, Weicheng3; Dou, Fangyuan3; Yao, Yunfeng2; Gu, Jin2
关键词chemokine colorectal cancer immunohistochemistry metastasis surgery
刊名HISTOPATHOLOGY
2013-08-01
DOI10.1111/his.12127
63期:2页:167-173
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]LYMPH-NODE METASTASIS ; COLON-CARCINOMA ; INFLAMMATION ; INHIBITION ; CCL20 ; LIVER ; RISK
英文摘要

AimsThe liver and lung are the organs most commonly affected by metastasis in colorectal cancer (CRC), and the interaction of chemokines and chemokine receptors (CKRs) plays an important role in the metastatic process. The aim of this study was to investigate the organ specificity of CKRs in CRC distant metastasis.

Methods and resultsSurgical specimens of primary tumours from 46 patients with metachronous distant metastases were retrieved retrospectively (20 lung metastases; 26 liver metastases). As a control, the records of 29 patients without distant metastases were randomly retrieved from our database, and their specimens were reassessed. The expression rates of CKRs, including CCR6, CXCR2, and CXCR4, were determined by immunohistochemistry, and were compared among the groups. The expression rates of CCR6 and CXCR2 were both significantly higher in the metastasis group than in the non-metastasis group (P<0.05), but there was no statistical difference between the lung metastasis and liver metastasis subgroups. The expression of CXCR4 was not significantly different between the metastasis and non-metastasis groups. Multivariable analysis suggested that preoperative serum carcinoembryonic antigen level, CCR6 and CXCR2 were independent factors associated with distant metastasis.

ConclusionsThe expression of CCR6 and CXCR2 in CRC could predict metachronous distant metastasis, but they have no organ specificity for metastasis.

语种英语
WOS记录号WOS:000329278300003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58660
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
2.Peking Univ, Canc Hosp, Dept Colorectal Surg, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
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Hu, Dongzhi,Du, Changzheng,Xue, Weicheng,et al. The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study[J]. HISTOPATHOLOGY,2013,63(2):167-173.
APA Hu, Dongzhi,Du, Changzheng,Xue, Weicheng,Dou, Fangyuan,Yao, Yunfeng,&Gu, Jin.(2013).The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study.HISTOPATHOLOGY,63(2),167-173.
MLA Hu, Dongzhi,et al."The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study".HISTOPATHOLOGY 63.2(2013):167-173.
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