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学科主题: 口腔医学
题名:
An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized submandibular gland transplantation
作者: Ge, Xi-yuan2; Yu, Guang-yan1; Fu, Jia2; Wu, Deng-cheng2; Zhang, Xiao-xia2; Wang, Yi-xiang2; Li, Sheng-lin2
关键词: Submandibular gland ; Autologous transplantation ; Keratoconjunctivitis sicca
刊名: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
发表日期: 2012-09-01
DOI: 10.1016/j.bjoms.2011.10.004
卷: 50, 期:6, 页:562-566
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
英文摘要:

We have evaluated transplantation of reduced submandibular glands for the treatment of severe keratoconjunctivitis sicca. Thirty-four rabbits were allocated into three groups: dry eye (controls, n = 10), transplantation of whole submandibular glands (a = 12), and transplantation of reduced submandibular glands (a = 12). Outcome measures included the results of Schirmer′s test and the Rose Bengal test, and histological examination of the cornea and the transplanted gland. Volume of tears significantly increased after transplantation of the whole gland, but did not change after transplantation of the reduced gland compared with dry eyes induced preoperatively. Neither transplantion group had keratoconjunctivitis sicca postoperatively. There were no histological abnormalities in the transplanted tissues. The results that the surgical technique of using reduced submandibular glands for transplantation was feasible, and that the secretion from the reduced gland was similar to that from a normal lacrimal gland. In conclusion, transplantation of a reduced submandibular glands is feasible in the treatment of keratoconjunctivitis sicca. (c) 2011 Published by Elsevier Ltd on behalf of The British Association of Oral and Maxillofacial Surgeons.

语种: 英语
所属项目编号: 30730102 ; 81070847 ; 2007BAI18B11 ; 2005-2009
项目资助者: National Natural Science Foundation of China ; National Supporting Program for Science and Technology ; Capital Medical Development Foundation ; Science Foundation of Peking University School ; Hospital of Stomatology
WOS记录号: WOS:000308518700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58662
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Cent Lab, Beijing 100871, Peoples R China

Recommended Citation:
Ge, Xi-yuan,Yu, Guang-yan,Fu, Jia,et al. An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized subman E ion[J]. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,2012,50(6):562-566.
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