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学科主题: 口腔医学
题名:
FOXO1 promotes wound healing through the up-regulation of TGF-beta 1 and prevention of oxidative stress
作者: Ponugoti, Bhaskar1; Xu, Fanxing1,2; Zhang, Chenying1,3; Tian, Chen1; Pacios, Sandra1,4; Graves, Dana T.1
刊名: JOURNAL OF CELL BIOLOGY
发表日期: 2013-10-28
DOI: 10.1083/jcb.201305074
卷: 203, 期:2, 页:327-343
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: FORKHEAD TRANSCRIPTION FACTORS ; EPIDERMAL-GROWTH-FACTOR ; CELL-MIGRATION ; CUTANEOUS WOUNDS ; REPAIR ; EXPRESSION ; HOMEOSTASIS ; BETA-1 ; REEPITHILIALIZATION ; ALPHA-V-BETA-6
英文摘要:

Keratinocyte mobilization is a critical aspect of wound re-epithelialization, but the mechanisms that control its precise regulation remain poorly understood. We set out to test the hypothesis that forkhead box O1 (FOXO1) has a negative effect on healing because of its capacity to inhibit proliferation and promote apoptosis. Contrary to expectations, FOXO1 is required for keratinocyte transition to a wound-healing phenotype that involves increased migration and up-regulation of transforming growth factor beta 1 (TGF-beta 1) and its downstream targets, integrin-alpha 3 and -beta 6 and MMP-3 and -9. Furthermore, we show that FOXO1 functions in keratinocytes to reduce oxidative stress, which is necessary to maintain cell migration and prevent cell death in a TGF-beta 1-independent manner. Thus, our studies identify a novel function for FOXO1 in coordinating the response of keratinocytes to wounding through up-regulation of TGF-beta 1 and other factors needed for keratinocyte migration and protection against oxidative stress, which together promote migration and decrease apoptosis.

语种: 英语
所属项目编号: DE019108
项目资助者: National Institute of Dental and Craniofacial Research
WOS记录号: WOS:000326281200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58665
Appears in Collections:北京大学口腔医学院_口腔预防保健科_期刊论文

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作者单位: 1.Univ Penn, Sch Dent Med, Philadelphia, PA 19104 USA
2.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100081, Peoples R China
4.Univ Int Catalunya, Sch Dent Med, Sant Cugat Del Valles 08195, Spain

Recommended Citation:
Ponugoti, Bhaskar,Xu, Fanxing,Zhang, Chenying,et al. FOXO1 promotes wound healing through the up-regulation of TGF-beta 1 and prevention of oxidative stress[J]. JOURNAL OF CELL BIOLOGY,2013,203(2):327-343.
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