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学科主题: 基础医学
题名:
Stereoselective synthesis of jaspine B from D-xylose
作者: Liu, Jun; Du, Yuguo; Dong, Xiaomin; Meng, Shucong; Xiao, Junjun; Cheng, Lijian
关键词: natural products ; jaspine B ; antitumor activity ; carbohydrates ; total synthesis
刊名: CARBOHYDRATE RESEARCH
发表日期: 2006-11-27
DOI: 10.1016/j.carres.2006.08.011
卷: 341, 期:16, 页:2653-2657
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: CYTOTOXIC ANHYDROPHYTOSPHINGOSINE ; STEREOCONTROLLED SYNTHESIS ; GLYCOSIDASE INHIBITORS ; INDUCED CYCLIZATION ; MARINE SPONGE ; PACHASTRISSAMINE ; SPHINGOLIPIDS ; TETRAHYDROFURAN ; PHYTOSPHINGOSINE ; METABOLISM
英文摘要:

The natural cytotoxic marine compound, jaspine B, is stereo selectively synthesized from D-Xylose in 11 linear steps with a 23.9% overall yield. The key step in the synthesis involves an iodine-induced debenzylation of a primary alcohol and the subsequent 2,5-cyclization to fit the required configuration of jaspine B. A preliminary bioassay shows strong inhibition activities against human MDA231, Hela, and CNE cell lines, indicating potential usage in various cancer treatments. (c) 2006 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000242007800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58667
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Basic Med Coll, Dept Cell Biol, Beijing 100083, Peoples R China
3.China Univ Min & Technol, Sch Chem & Environm Engn, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Jun,Du, Yuguo,Dong, Xiaomin,et al. Stereoselective synthesis of jaspine B from D-xylose[J]. CARBOHYDRATE RESEARCH,2006,341(16):2653-2657.
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