IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Stereoselective synthesis of jaspine B from D-xylose
Liu, Jun; Du, Yuguo; Dong, Xiaomin; Meng, Shucong; Xiao, Junjun; Cheng, Lijian
关键词natural products jaspine B antitumor activity carbohydrates total synthesis
刊名CARBOHYDRATE RESEARCH
2006-11-27
DOI10.1016/j.carres.2006.08.011
341期:16页:2653-2657
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]CYTOTOXIC ANHYDROPHYTOSPHINGOSINE ; STEREOCONTROLLED SYNTHESIS ; GLYCOSIDASE INHIBITORS ; INDUCED CYCLIZATION ; MARINE SPONGE ; PACHASTRISSAMINE ; SPHINGOLIPIDS ; TETRAHYDROFURAN ; PHYTOSPHINGOSINE ; METABOLISM
英文摘要

The natural cytotoxic marine compound, jaspine B, is stereo selectively synthesized from D-Xylose in 11 linear steps with a 23.9% overall yield. The key step in the synthesis involves an iodine-induced debenzylation of a primary alcohol and the subsequent 2,5-cyclization to fit the required configuration of jaspine B. A preliminary bioassay shows strong inhibition activities against human MDA231, Hela, and CNE cell lines, indicating potential usage in various cancer treatments. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000242007800003
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58667
专题北京大学基础医学院_细胞生物学系
作者单位1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Basic Med Coll, Dept Cell Biol, Beijing 100083, Peoples R China
3.China Univ Min & Technol, Sch Chem & Environm Engn, Beijing 100083, Peoples R China
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GB/T 7714
Liu, Jun,Du, Yuguo,Dong, Xiaomin,et al. Stereoselective synthesis of jaspine B from D-xylose[J]. CARBOHYDRATE RESEARCH,2006,341(16):2653-2657.
APA Liu, Jun,Du, Yuguo,Dong, Xiaomin,Meng, Shucong,Xiao, Junjun,&Cheng, Lijian.(2006).Stereoselective synthesis of jaspine B from D-xylose.CARBOHYDRATE RESEARCH,341(16),2653-2657.
MLA Liu, Jun,et al."Stereoselective synthesis of jaspine B from D-xylose".CARBOHYDRATE RESEARCH 341.16(2006):2653-2657.
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