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学科主题: 基础医学
题名:
Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity
作者: Zhang, Jie1; Niu, Na2; Li, Bingjie3; McNutt, Michael A.4
关键词: endogenous IgG ; CD64 ; neuron ; complement ; active immunity
刊名: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
发表日期: 2013-12-01
DOI: 10.1369/0022155413504196
卷: 61, 期:12, 页:869-879
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: MICROGLIA ; RECEPTORS ; BRAIN ; IMMUNOGLOBULINS ; EXPRESSION ; ANTIBODY ; DISEASE ; SYSTEM ; GROWTH ; ALPHA
英文摘要:

Passive immunity of the nervous system has traditionally been thought to be predominantly due to the blood-brain barrier. This concept must now be revisited based on the existence of neuron-derived IgG. The conventional concept is that IgG is produced solely by mature B lymphocytes, but it has now been found to be synthesized by murine and human neurons. However, the function of this endogenous IgG is poorly understood. In this study, we confirm IgG production by rat cortical neurons at the protein and mRNA levels, with 69.0 +/- 5.8% of cortical neurons IgG-positive. Injury to primary-culture neurons was induced by complement leading to increases in IgG production. Blockage of neuron-derived IgG resulted in more neuronal death and early apoptosis in the presence of complement. In addition, FcRI was found in microglia and astrocytes. Expression of FcR I in microglia was increased by exposure to neuron-derived IgG. Release of NO from microglia triggered by complement was attenuated by neuron-derived IgG, and this attenuation could be reversed by IgG neutralization. These data demonstrate that neuron-derived IgG is protective of neurons against injury induced by complement and microglial activation. IgG appears to play an important role in maintaining the stability of the nervous system.

语种: 英语
所属项目编号: 81100885 ; BS2011SW051
项目资助者: National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province
WOS记录号: WOS:000327294200002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58671
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Weifang Med Univ, Dept Human Anat, Weifang 261053, Peoples R China
2.Weifang Med Univ, Weifang 261053, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77030 USA
4.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Jie,Niu, Na,Li, Bingjie,et al. Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,2013,61(12):869-879.
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