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学科主题基础医学
Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity
Zhang, Jie1; Niu, Na2; Li, Bingjie3; McNutt, Michael A.4
关键词endogenous IgG CD64 neuron complement active immunity
刊名JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
2013-12-01
DOI10.1369/0022155413504196
61期:12页:869-879
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
资助者National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province
研究领域[WOS]Cell Biology
关键词[WOS]MICROGLIA ; RECEPTORS ; BRAIN ; IMMUNOGLOBULINS ; EXPRESSION ; ANTIBODY ; DISEASE ; SYSTEM ; GROWTH ; ALPHA
英文摘要

Passive immunity of the nervous system has traditionally been thought to be predominantly due to the blood-brain barrier. This concept must now be revisited based on the existence of neuron-derived IgG. The conventional concept is that IgG is produced solely by mature B lymphocytes, but it has now been found to be synthesized by murine and human neurons. However, the function of this endogenous IgG is poorly understood. In this study, we confirm IgG production by rat cortical neurons at the protein and mRNA levels, with 69.0 +/- 5.8% of cortical neurons IgG-positive. Injury to primary-culture neurons was induced by complement leading to increases in IgG production. Blockage of neuron-derived IgG resulted in more neuronal death and early apoptosis in the presence of complement. In addition, FcRI was found in microglia and astrocytes. Expression of FcR I in microglia was increased by exposure to neuron-derived IgG. Release of NO from microglia triggered by complement was attenuated by neuron-derived IgG, and this attenuation could be reversed by IgG neutralization. These data demonstrate that neuron-derived IgG is protective of neurons against injury induced by complement and microglial activation. IgG appears to play an important role in maintaining the stability of the nervous system.

语种英语
所属项目编号81100885 ; BS2011SW051
资助者National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province
WOS记录号WOS:000327294200002
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58671
专题北京大学基础医学院_病理学系
作者单位1.Weifang Med Univ, Dept Human Anat, Weifang 261053, Peoples R China
2.Weifang Med Univ, Weifang 261053, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77030 USA
4.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Jie,Niu, Na,Li, Bingjie,et al. Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,2013,61(12):869-879.
APA Zhang, Jie,Niu, Na,Li, Bingjie,&McNutt, Michael A..(2013).Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity.JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,61(12),869-879.
MLA Zhang, Jie,et al."Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity".JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 61.12(2013):869-879.
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