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学科主题: 临床医学
题名:
Comparison of Iris Insertion Classification Among American Caucasian and Ethnic Chinese Using Ultrasound Biomicroscopy
作者: Wang, Ye Elaine1,2; Li, Yingjie1,3; Wang, Dandan1,4; He, Mingguang4; Wu, Lingling5; Lin, Shan C.1
关键词: UBM ; interethnic comparison ; iris insertion ; angle closure ; PACG
刊名: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
发表日期: 2013-06-01
DOI: 10.1167/iovs.12-11585
卷: 54, 期:6, 页:3837-3843
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: OPTICAL COHERENCE TOMOGRAPHY ; ANGLE-CLOSURE GLAUCOMA ; ANTERIOR SEGMENT ; MAINLAND CHINESE ; ADULT CHINESE ; NARROW ANGLES ; ASSOCIATION ; PREVALENCE ; WIDTH ; CONFIGURATION
英文摘要:

PURPOSE. To qualitatively classify and compare types of iris insertion among American Caucasians, American Chinese, and mainland Chinese.

METHODS. Prospective multicenter cross-sectional study. Sex- and age-matched Caucasian, American Chinese, and mainland Chinese cohorts were enrolled. Ultrasound biomicroscopy (UBM) images of the anterior chamber were acquired. Qualitative classification of iris insertion into basal, middle, and apical categories was performed. Proportions of each type of insertion were compared among racial groups. Multivariate logistic regression was carried out adjusting for potential confounders.

RESULTS. Data from 117, 129, and 112 subjects were available for American Caucasian, American Chinese, and mainland Chinese subjects, respectively. The most common type of iris insertion in the superior quadrant was basal insertion in both ethnic Chinese and Caucasians. In the inferior, nasal, and temporal quadrants, Chinese showed significantly higher proportions of nonbasal insertion (P = 0.048, P < 0.0001, P < 0.0001, respectively). After adjusting for confounders, nonbasal insertion was significantly associated with Chinese ethnicity in nasal and temporal quadrants (nasal, OR: 3.1, temporal, OR: 4.8). Increasing proportions of nonbasal insertion were found with advancing age in both Chinese and Caucasians.

CONCLUSIONS. Chinese have significantly higher proportions of nonbasal iris insertion in the nasal and temporal quadrants when compared with Caucasians, even after adjusting for ASOCT-measured anterior segment biometry and iris characteristics. Longitudinal studies in patients who have PAC/PACG are needed to fully elucidate the relationship between iris insertion and angle closure development.

语种: 英语
所属项目编号: EY002162 ; 81260147
项目资助者: National Eye Institute Grant ; National Natural Science Foundation of China Grant
WOS记录号: WOS:000321120700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58673
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Duke Univ, Sch Med, Durham, NC USA
2.Nanchang Univ, Affiliated Hosp 3, Nanchang, Peoples R China
3.Peking Univ, Ctr Eye, Hosp 3, Beijing 100871, Peoples R China
4.Univ Calif San Francisco, San Francisco, CA 94143 USA
5.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China

Recommended Citation:
Wang, Ye Elaine,Li, Yingjie,Wang, Dandan,et al. Comparison of Iris Insertion Classification Among American Caucasian and Ethnic Chinese Using Ultrasound Biomicroscopy[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2013,54(6):3837-3843.
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