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Epstein-Barr Virus-Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes
Xu, Lan-Ping1; Zhang, Chun-Li2; Mo, Xiao-Dong1; Zhang, Xiao-Hui1; Chen, Huan1; Han, Wei1; Chen, Yu-Hong1; Wang, Yu1; Yan, Chen-Hua1; Wang, Jing-Zhi1; Wang, Feng-Rong1; Zhao, Ting1; Liu, Yan-Rong1; Liu, Kai-Yan1; Huang, Xiao-Jun1,3,4
关键词Epstein-Barr virus-related post-transplantation lymphoproliferative disorder Haploidentical Hematopoietic stem cell transplantation Immune reconstitution Rituximab
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2015-12-01
DOI10.1016/j.bbmt.2015.07.035
21期:12页:2185-2191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; HEMATOLOGICAL MALIGNANCIES ; EBV REACTIVATION ; ACUTE-LEUKEMIA ; T-LYMPHOCYTES ; DISEASE ; BLOOD ; RECIPIENTS ; MANAGEMENT ; RITUXIMAB
英文摘要

We examined the incidence, risk factors, treatments, and clinical outcomes of post-transplantation lymphoproliferative disorder (PTLD) after unmanipulated haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) in 1184 patients between 2006 and 2012. Age-, transplantation time, and transplantation duration matched controls were randomly selected from the same cohort. Forty-five patients experienced PTLD. The median time from HSCT to PTLD occurrence was 61 (range, 33 to 360) days and the 1-year cumulative incidence of total PTLD after haplo-HSCT was 3.0%. In multivariate analysis, a lower absolute count of CD8(+) T lymphocytes at day 30, a lower absolute count of immunoglobulin M at day 30, and cytomegalovirus DNAemia after HSCT were significantly associated with higher risk of PTLD. The 2-year probability of overall survival (OS) after HSCT was 42.8%, which was comparable between the probable PTLD and the proven PTLD patients. Patients who received rituximab-based therapy had significantly better 2-year OS (48.2% versus 13.2%, P =.02). Thus, we were able to identify individuals at a high risk of developing PTLD after unmanipulated haplo-HSCT. Rituximab-based therapy can help to improve the outcomes of PTLD patients. (c) 2015 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000364981700023
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58674
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
2.Beijing Hosp, Dept Hematol, Beijing, Peoples R China
3.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
4.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xu, Lan-Ping,Zhang, Chun-Li,Mo, Xiao-Dong,et al. Epstein-Barr Virus-Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2015,21(12):2185-2191.
APA Xu, Lan-Ping.,Zhang, Chun-Li.,Mo, Xiao-Dong.,Zhang, Xiao-Hui.,Chen, Huan.,...&Huang, Xiao-Jun.(2015).Epstein-Barr Virus-Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,21(12),2185-2191.
MLA Xu, Lan-Ping,et al."Epstein-Barr Virus-Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 21.12(2015):2185-2191.
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