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学科主题临床医学
Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression
Li, Song1; Guo, Bin1; Song, Jianwen1; Deng, Xiaoli1; Cong, Yusheng1; Li, Pengfei2; Zhao, Ke2; Liu, Lihong2; Xiao, Gang3; Xu, Feng4; Ye, Yingjiang4; Zhao, Zhenwen5; Yu, Menggang6; Xu, Yan5; Sang, Jianli1; Zhang, Junjie1
关键词Colorectal cancer Adenomatous polyps Phospholipids Mass spectrometry Biomarkers
刊名METABOLOMICS
2013-02-01
DOI10.1007/s11306-012-0439-z
9期:1页:202-212
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]COLON-CANCER ; LYSOPHOSPHATIDIC ACID ; SPHINGOSINE 1-PHOSPHATE ; SERUM MARKERS ; FECAL DNA ; LYSOPHOSPHOLIPIDS ; STOOL ; SPHINGOSYLPHOSPHORYLCHOLINE ; IDENTIFICATION ; PROLIFERATION
英文摘要

Colorectal cancer (CRC) is believed to progress through the adenoma-carcinoma sequence. The adenoma-carcinoma transition is an important window for early detection and intervention of CRC. In the present study, plasma samples from patients with CRC (n = 120), patients with adenomatous polyps (AP) (n = 120), and healthy controls (n = 120) were collected. Plasma phospholipid levels were analyzed with liquid chromatography-tandem mass spectrometry. It was found that the plasma levels of major lysophosphatidylcholine (LPC) species were gradationally decreased from healthy controls, AP to CRC subjects. A formula including total saturated LPCs, 18:2 LPC and sphingosylphosphorylcholine (SPC) yielded a sensitivity and specificity of 88.3 and 80 % for separating CRC from healthy controls. An optimized model with total saturated LPCs, 20:4 LPC and sphingomyelins (SM) as markers yielded a sensitivity and specificity of 89 and 80 % for separating AP from the healthy controls. Moreover, with SM, SPC and saturated LPCs as markers, a model was made to separate CRC from AP with the sensitivity and specificity of 90 and 92.5 %, respectively. These data indicate that the plasma choline-containing phospholipid levels represent potential biomarkers to distinguish between healthy controls, AP and CRC cases, implying their clinical usage in CRC and/or AP-CRC progression detection.

语种英语
WOS记录号WOS:000313736700017
项目编号31070714 ; 2006AA02Z4A6 ; Z0006329000191 ; 105566GK ; 2005B47
资助机构National Nature Science Foundation of China ; National High Technology Research and Development Program, China ; Science and Technology Program of Beijing Municipality ; Fundamental Research Funds for the Central Universities ; Beijing NOVA Program ; Indiana University
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58676
专题北京大学第二临床医学院
北京大学药学院_天然药物学系
作者单位1.Beijing Normal Univ, Key Lab Cell Proliferat & Regulat Biol, Minist Educ, Inst Cell Biol,Coll Life Sci, Beijing 100875, Peoples R China
2.Gen Hosp Second Artillery Force Chinese PLA, Beijing 100088, Peoples R China
3.Beijing Hosp, Beijing 100730, Peoples R China
4.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
5.Indiana Univ Sch Med, Indiana Univ Canc Ctr, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA
6.Indiana Univ Sch Med, Div Biostat, Indianapolis, IN 46202 USA
推荐引用方式
GB/T 7714
Li, Song,Guo, Bin,Song, Jianwen,et al. Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression[J]. METABOLOMICS,2013,9(1):202-212.
APA Li, Song.,Guo, Bin.,Song, Jianwen.,Deng, Xiaoli.,Cong, Yusheng.,...&Zhang, Junjie.(2013).Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression.METABOLOMICS,9(1),202-212.
MLA Li, Song,et al."Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression".METABOLOMICS 9.1(2013):202-212.
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