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学科主题临床医学
Lipoprotein glomerulopathy in China
Chen, Yuqing1,2
关键词Lipoprotein glomerulopathy APOE Mutation
刊名CLINICAL AND EXPERIMENTAL NEPHROLOGY
2014-04-01
DOI10.1007/s10157-013-0873-x
18期:2页:218-219
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ACID DELETION ; MUTATION ; VARIANT ; APOE
英文摘要

Lipoprotein glomerulopathy (LPG), a rare renal disease, is mainly reported in Japan and China. Chinese cases of LPG showed similar clinical and pathological features as reports from other countries. Three types of APOE mutation have been detected in those patients: APOE Maebashi (142Arg-144Leu-0) and APOE Kyoto (Arg25-Cys) were initially reported, and APOE Guangzhou (Arg150-Pro) is a novel mutation in Chinese patients with LPG. Asymptomatic carriers of all three mutations exist in families, but serum lipid and apolipoprotein E (apoE) levels are markedly elevated. In most of Chinese patients with LPG, long-term treatment with statins or bezafibrates appears to decrease proteinuria. LPG provides a disease model by which to explore pathogenic roles of apoE in common diseases.

语种英语
WOS记录号WOS:000334874100010
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58681
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Internal Med, Hosp 1, Div Renal, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yuqing. Lipoprotein glomerulopathy in China[J]. CLINICAL AND EXPERIMENTAL NEPHROLOGY,2014,18(2):218-219.
APA Chen, Yuqing.(2014).Lipoprotein glomerulopathy in China.CLINICAL AND EXPERIMENTAL NEPHROLOGY,18(2),218-219.
MLA Chen, Yuqing."Lipoprotein glomerulopathy in China".CLINICAL AND EXPERIMENTAL NEPHROLOGY 18.2(2014):218-219.
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