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学科主题: 基础医学
题名:
Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat
作者: Cui, CL; Wu, LZ; Han, JS
关键词: kappa-opioid receptor ; morphine withdrawal syndrome ; trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzenacetamide hydrochloride ; nor-binaltorphimine ; spinal cord ; naloxone
刊名: NEUROSCIENCE LETTERS
发表日期: 2000-12-01
卷: 295, 期:1-2, 页:45-48
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NOR-BINALTORPHIMINE ; IDENTIFIED FREQUENCIES ; PHYSICAL-DEPENDENCE ; ABSTINENCE SYNDROME ; OPIATE WITHDRAWAL ; DYNORPHIN ; TOLERANCE ; RECEPTOR ; STIMULATION ; ANTAGONIST
英文摘要:

To explore the possible involvement of spinal K-opioid receptor in modulating morphine withdrawal syndrome, rats were made dependent on morphine by multiple injections of morphine HCl for 5 days. They were then given intrathecal administration (i.t.) of a kappa -opioid receptor agonist trans-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl)-cyclohexyl]-benzenacetamide hydrochloride (U-50,488H, 2.5-10 mug) or its antagonist nor-binaltorphimine (nor-BNI, 1.25-5 mug), followed by intraperitoneal administration (i.p.) of naloxone (0.5 mg/kg), and the withdrawal syndrome was scored for 60 min. U-50,488H produced a dose-dependent suppression, whereas nor-BNI a dose-dependent potentiation in withdrawal syndrome. The latter result implies that an endogenous kappa receptor agonist, most probably dynorphin, exerts a tonic suppressive effect on morphine syndrome at spinal level. (C) 2000 Elsevier Science Ireland Ltd. AII rights reserved.

语种: 英语
WOS记录号: WOS:000165562200012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58683
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Cui, CL,Wu, LZ,Han, JS. Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat[J]. NEUROSCIENCE LETTERS,2000,295(1-2):45-48.
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