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Sustained-Release Bupropion for Smoking Cessation in a Chinese Sample: A Double-Blind, Placebo-Controlled, Randomized Trial
Sheng, Li-xia1,2,3; Tang, Yi-lang4; Jiang, Zuo-ning2; Yao, Chong-hua5; Gao, Jun-yu6; Xu, Guo-Zhu7; Tong, Xin-yuan8
刊名NICOTINE & TOBACCO RESEARCH
2013-02-01
DOI10.1093/ntr/nts124
15期:2页:320-325
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse ; Public, Environmental & Occupational Health
研究领域[WOS]Substance Abuse ; Public, Environmental & Occupational Health
关键词[WOS]CLINICAL-TRIAL ; SMOKERS ; DEPRESSION ; PREVALENCE ; PREDICTORS ; REDUCTION
英文摘要

Bupropion is a first-line pharmacological aid for smoking cessation; however, no clinical trials have been conducted in a Chinese population.

We enrolled 248 smokers in a hospital-based, randomized, smoking cessation trial conducted at four outpatient centers in Beijing. A total of 123 participants received an 8-week course of sustained-release bupropion (Bup-SR) and 125 participants received 8 weeks of placebo. All participants received brief education and counseling on smoking cessation. We determined rates of abstinence and smoking reduction based on chemical verification and self-report at 8 and 12 weeks.

At the end of the medication treatment (8 weeks) and at the end of the trial (12 weeks), the abstinence rates for Bup-SR were 29.3% and 39.8%, respectively, and 10.4% and 8.0% for placebo, respectively (both p < .001). Bup-SR was also superior to placebo in reducing cigarettes per day and urinary cotinine levels.

Bup-SR is efficacious for smoking cessation in healthy Chinese patients treated in the outpatient setting. It is well tolerated with a few mild side effects.

语种英语
WOS记录号WOS:000313826600002
资助机构Zhejiang Jinxin Pharmaceutical Co, Ltd.
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58686
专题中国药物依赖性研究所
作者单位1.Capital Med Univ, Beijing Anding Hosp, Dept Med Affairs, Beijing 100088, Peoples R China
2.Natl Drug Dependence Treatment Ctr, Beijing, Peoples R China
3.Natl Ctr Clin Trials Psychotrop Drugs, Beijing, Peoples R China
4.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
5.PLA Med Coll Continuat Educ, Dept Med Stat, Beijing, Peoples R China
6.Capital Med Univ, Beijing Anzhen Hosp, Beijing 100088, Peoples R China
7.Acad Mil Med Sci, Affiliated Hosp, Beijing, Peoples R China
8.Peking Univ, Hlth Sci Ctr, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Sheng, Li-xia,Tang, Yi-lang,Jiang, Zuo-ning,et al. Sustained-Release Bupropion for Smoking Cessation in a Chinese Sample: A Double-Blind, Placebo-Controlled, Randomized Trial[J]. NICOTINE &amp; TOBACCO RESEARCH,2013,15(2):320-325.
APA Sheng, Li-xia.,Tang, Yi-lang.,Jiang, Zuo-ning.,Yao, Chong-hua.,Gao, Jun-yu.,...&Tong, Xin-yuan.(2013).Sustained-Release Bupropion for Smoking Cessation in a Chinese Sample: A Double-Blind, Placebo-Controlled, Randomized Trial.NICOTINE & TOBACCO RESEARCH,15(2),320-325.
MLA Sheng, Li-xia,et al."Sustained-Release Bupropion for Smoking Cessation in a Chinese Sample: A Double-Blind, Placebo-Controlled, Randomized Trial".NICOTINE & TOBACCO RESEARCH 15.2(2013):320-325.
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