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Using a Low-Sodium, High-Potassium Salt Substitute to Reduce Blood Pressure among Tibetans with High Blood Pressure: A Patient-Blinded Randomized Controlled Trial
Zhao, Xingshan1; Yin, Xuejun2; Li, Xian2; Yan, Lijing L.2,3; Lam, Christopher T.4; Li, Shenshen2; He, Feng1; Xie, Wuxiang5; Ba, Sang6; Luobu, Gesang7; Ke, Liang2; Wu, Yangfeng2,5
刊名PLOS ONE
2014-10-22
DOI10.1371/journal.pone.0110131
9期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]LIFE-STYLE MODIFICATION ; RISK-FACTORS ; CHINA ; HYPERTENSION ; METAANALYSIS ; TEMPERATURE ; ALTITUDES ; DISEASES ; STATINS ; PEOPLES
英文摘要

Objectives: To evaluate the effects of a low-sodium and high-potassium salt-substitute on lowering blood pressure (BP) among Tibetans living at high altitude (4300 meters).

Method: The study was a patient-blinded randomized controlled trial conducted between February and May 2009 in Dangxiong County, Tibetan Autonomous Region, China. A total of 282 Tibetans aged 40 or older with known hypertension (systolic BP >= 140 mmHg) were recruited and randomized to intervention (salt-substitute, 65% sodium chloride, 25% potassium chloride and 10% magnesium sulfate) or control (100% sodium chloride) in a 1: 1 allocation ratio with three months′ supply. Primary outcome was defined as the change in BP levels measured from baseline to followed-up with an automated sphygmomanometer. Per protocol (PP) and intention to treat (ITT) analyses were conducted.

Results: After the three months′ intervention period, the net reduction in SBP/DBP in the intervention group in comparison to the control group was -8.2/-3.4 mmHg (all p<0.05) in PP analysis, after adjusting for baseline BP and other variables. ITT analysis showed the net reduction in SBP/DBP at -7.6/-3.5 mmHg with multiple imputations (all p<0.05). Furthermore, the whole distribution of blood pressure showed an overall decline in SBP/DBP and the proportion of patients with BP under control (SBP/DBP, 140 mmHg) was significantly higher in salt-substitute group in comparison to the regular salt group (19.2% vs. 8.8%, p=0.027).

Conclusion: Low sodium high potassium salt-substitute is effective in lowering both systolic and diastolic blood pressure and offers a simple, low-cost approach for hypertension control among Tibetans in China.

语种英语
WOS记录号WOS:000343674800025
项目编号08-04-06 ; HHSN268200900027C ; 2013BAI05B04
资助机构Bureau of Science and Technology of Tibet Autonomous Region ; United States National Heart, Lung, and Blood Institute (National Institutes of Health) ; UnitedHealth Group Chronic Disease Initiative ; People&prime ; s Republic of China Ministry of Science and Technology
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58700
专题北京大学公共卫生学院
作者单位1.Duke Univ, Duke Global Hlth Inst, Durham, NC USA
2.Dangxiong Peoples Hosp, Dangxiong, Tibet, Peoples R China
3.Tibet Autonomous Reg Peoples Hosp, Lhasa, Tibet, Peoples R China
4.Peking Univ, Beijing Jishuitan Hosp, Coll Med 4, Dept Cardiol, Beijing 100871, Peoples R China
5.Peking Univ, George Inst Global Hlth, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
7.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xingshan,Yin, Xuejun,Li, Xian,et al. Using a Low-Sodium, High-Potassium Salt Substitute to Reduce Blood Pressure among Tibetans with High Blood Pressure: A Patient-Blinded Randomized Controlled Trial[J]. PLOS ONE,2014,9(10).
APA Zhao, Xingshan.,Yin, Xuejun.,Li, Xian.,Yan, Lijing L..,Lam, Christopher T..,...&Wu, Yangfeng.(2014).Using a Low-Sodium, High-Potassium Salt Substitute to Reduce Blood Pressure among Tibetans with High Blood Pressure: A Patient-Blinded Randomized Controlled Trial.PLOS ONE,9(10).
MLA Zhao, Xingshan,et al."Using a Low-Sodium, High-Potassium Salt Substitute to Reduce Blood Pressure among Tibetans with High Blood Pressure: A Patient-Blinded Randomized Controlled Trial".PLOS ONE 9.10(2014).
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