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学科主题: 精神卫生
题名:
Adjunctive Mood Stabilizer and Benzodiazepine Use in Older Asian Patients with Schizophrenia, 2001-2009
作者: Xiang, Y. -T.1,2; Dickerson, F.3; Kreyenbuhl, J.4,5; Ungvari, G. S.6; Wang, C. -Y.2; Si, T. -M.7; Lee, E. H. M.1; He, Y. -L.8; Chiu, H. F. K.1; Yang, S. -Y.9; Chong, M. -Y.10,11; Tan, C. -H.12; Kua, E. -H.12; Fujii, S.13; Sim, K.14; Yong, M. K. H.14; Trivedi, J. K.15; Chung, E. -K.16; Udomratn, P.17; Chee, K. -Y.18; Sartorius, N.19; Shinfuku, N.20
关键词: schizophrenia ; prescription patterns ; mood stabilizers ; benzodiazepines ; older patients ; Asia
刊名: PHARMACOPSYCHIATRY
发表日期: 2012-09-01
DOI: 10.1055/s-0031-1301292
卷: 45, 期:6, 页:217-222
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: PSYCHOTROPIC-DRUG PRESCRIPTION ; QUALITY-OF-LIFE ; LONG-TERM USE ; ATYPICAL ANTIPSYCHOTICS ; EAST-ASIA ; INPATIENTS ; PHARMACOTHERAPY ; GUIDELINES ; EFFICACY ; AGENTS
英文摘要:

Objective: This study surveyed the use of adjunctive mood stabilizers (MS) and benzodiazepines (BZD) in older Asian schizophrenia patients and examined their demographic and clinical correlates.

Method: Information on hospitalized schizophrenia patients aged 55 years or more were extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study. A total of 1 452 patients from 9 Asian countries and territories was included in the study. The patients′ sociodemographic and clinical characteristics and the prescriptions of antipsychotics, MS and BZD were recorded using a standardized protocol and data collection procedure.

Results: The frequency of MS prescription was 26.7% in the pooled sample, with 25.5% in 2001, 26.9% in 2004 and 27.7% in 2009. The corresponding figures for BZD were 20.7%, 20.2%, 18.4% and 23.1%, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on MS were younger and more likely to be men and to have extrapyramidal side effects (EPS) and a longer duration of illness. Compared to patients in China, those in Japan were more likely to receive MS, while Korean patents were prescribed less MS. In contrast, there were no significant sociodemographic or clinical correlates of BZD use. Compared to patients in China, their Korean and Singaporean counterparts were more likely to be on BZD.

Conclusions: The use of MS and BZD is not uncommon in older Asian patients with schizophrenia. Given the paucity of empirical data on the efficacy of these agents in individuals with schizophrenia of any age and concerns about added side effects in older patients in particular, the rationale for the prescription of these agents in this population warrants further examination.

语种: 英语
所属项目编号: 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Science Foundation of China ; Beijing Nova Program of the Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong (Direct Grant for Research) ; Institute of Mental Health Research Grant in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000309321300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58702
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
2.Vet Adm Capitol Healthcare Network VISN 5, MIRECC, Baltimore, MD USA
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
5.Taipei City Hosp, Taipei, Taiwan
6.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
7.Chang Gung Univ, Sch Med, Gueishan, Taiwan
8.Natl Univ Singapore, Singapore 117548, Singapore
9.HITS, Kobe, Hyogo, Japan
10.Inst Mental Hlth, Buangkok View, Singapore
11.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
12.Natl Seoul Hosp, Seoul, South Korea
13.Chinese Univ Hong Kong, Dept Psychiat, Tai Po, Hong Kong, Peoples R China
14.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
15.Univ Maryland, Sch Med, Dept Psychiat, Div Serv Res, Baltimore, MD 21201 USA
16.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
17.Prince Songkla Univ, Hat Yai, Thailand
18.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
19.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
20.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan

Recommended Citation:
Xiang, Y. -T.,Dickerson, F.,Kreyenbuhl, J.,et al. Adjunctive Mood Stabilizer and Benzodiazepine Use in Older Asian Patients with Schizophrenia, 2001-2009[J]. PHARMACOPSYCHIATRY,2012,45(6):217-222.
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