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学科主题临床医学
XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis
Liu, Chuan1; Yin, Qinghua2; Li, Lian3; Jiao, Guangjun4; Wang, Mei1; Wang, Yajie1
关键词meta-analysis XRCC1 Arg194Trp Arg280His bladder cancer
刊名CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
2013
23期:4页:339-354
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]EXCISION-REPAIR PATHWAY ; DNA-REPAIR ; GENETIC POLYMORPHISMS ; GASTRIC-CANCER ; RISK ; SMOKING ; ASSOCIATIONS ; ESOPHAGEAL ; VARIANTS ; PROTEIN
英文摘要

The XRCC1 Arg194Trp and Arg280His polymorphisms were likely to be involved with the development of bladder cancer. However, there had been inconsistent reports of association. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science for relevant articles with a time limit of April 25, 2013. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between the two polymorphisms and bladder cancer susceptibility using a random-effects model. This meta-analysis including 14 case-control studies evaluated the associations between the two XRCC1 polymorphisms and bladder cancer susceptibility. Overall, for Arg194Trp, significant associations were found in TT versus CC (OR = 1.78, 95% CI = 1.12-2.82) and the recessive model (OR = 1.71, 95% CI = 1.11-2.65); for Arg280His, significant associations were also found in AG versus GG (OR = 1.63, 95% CI =1.24-2.13) and the dominant model (OR =1.39, 95% CI = 1.07-1.82). When stratified by ethnicity, in Asian population, significant associations were found for Arg194Trp polymorphism in TT versus CC (OR = 2.99, 95% CI = 1.48-6.06), the dominant model (OR = 1.33, 95% CI = 1.03-1.72) and the recessive model (OR = 2.72, 95% CI = 1.36-5.45), and for Arg280His in GA versus GG (OR = 2.13, 95% CI = 1.63-2.97), but no significant associations were found in no-Asian population. This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.

语种英语
WOS记录号WOS:000327166800006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58711
专题北京大学第二临床医学院_骨肿瘤科
作者单位1.Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai 200433, Peoples R China
2.First Peoples Hosp Yueyang, Dept Oncol, Yueyang, Peoples R China
3.Yueyang Second Peoples Hosp, Yueyang 414000, Peoples R China
4.Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Chuan,Yin, Qinghua,Li, Lian,et al. XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis[J]. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION,2013,23(4):339-354.
APA Liu, Chuan,Yin, Qinghua,Li, Lian,Jiao, Guangjun,Wang, Mei,&Wang, Yajie.(2013).XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis.CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION,23(4),339-354.
MLA Liu, Chuan,et al."XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis".CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 23.4(2013):339-354.
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