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学科主题: 临床医学
题名:
XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis
作者: Liu, Chuan1; Yin, Qinghua2; Li, Lian3; Jiao, Guangjun4; Wang, Mei1; Wang, Yajie1
关键词: meta-analysis ; XRCC1 ; Arg194Trp ; Arg280His ; bladder cancer
刊名: CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
发表日期: 2013
卷: 23, 期:4, 页:339-354
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]: EXCISION-REPAIR PATHWAY ; DNA-REPAIR ; GENETIC POLYMORPHISMS ; GASTRIC-CANCER ; RISK ; SMOKING ; ASSOCIATIONS ; ESOPHAGEAL ; VARIANTS ; PROTEIN
英文摘要:

The XRCC1 Arg194Trp and Arg280His polymorphisms were likely to be involved with the development of bladder cancer. However, there had been inconsistent reports of association. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science for relevant articles with a time limit of April 25, 2013. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between the two polymorphisms and bladder cancer susceptibility using a random-effects model. This meta-analysis including 14 case-control studies evaluated the associations between the two XRCC1 polymorphisms and bladder cancer susceptibility. Overall, for Arg194Trp, significant associations were found in TT versus CC (OR = 1.78, 95% CI = 1.12-2.82) and the recessive model (OR = 1.71, 95% CI = 1.11-2.65); for Arg280His, significant associations were also found in AG versus GG (OR = 1.63, 95% CI =1.24-2.13) and the dominant model (OR =1.39, 95% CI = 1.07-1.82). When stratified by ethnicity, in Asian population, significant associations were found for Arg194Trp polymorphism in TT versus CC (OR = 2.99, 95% CI = 1.48-6.06), the dominant model (OR = 1.33, 95% CI = 1.03-1.72) and the recessive model (OR = 2.72, 95% CI = 1.36-5.45), and for Arg280His in GA versus GG (OR = 2.13, 95% CI = 1.63-2.97), but no significant associations were found in no-Asian population. This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.

语种: 英语
WOS记录号: WOS:000327166800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58711
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: 1.Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai 200433, Peoples R China
2.First Peoples Hosp Yueyang, Dept Oncol, Yueyang, Peoples R China
3.Yueyang Second Peoples Hosp, Yueyang 414000, Peoples R China
4.Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Chuan,Yin, Qinghua,Li, Lian,et al. XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis[J]. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION,2013,23(4):339-354.
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