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学科主题: 临床医学
题名:
Comparative study on the level of B lymphocyte stimulator (BlyS) and frequency of lymphocytes between sero-negative and sero-positive rheumatoid arthritis patients
作者: Geng, Yan; Zhang, Zhuo-li
关键词: B lymphocyte stimulator (BlyS) ; rheumatoid arthritis ; sero-negative ; sero-positive
刊名: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
发表日期: 2012-10-01
DOI: 10.1111/j.1756-185X.2012.01814.x
卷: 15, 期:5, 页:478-485
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: INFLAMMATORY ARTHRITIS ; AUTOIMMUNE-DISEASE ; BAFF ; CYTOKINE ; CELLS ; MICE ; TACI ; ACTIVATION ; RITUXIMAB ; SYNOVIUM
英文摘要:

Aim To investigate the differences of B lymphocyte stimulator (BlyS) level and frequency of lymphocytes between sero-negative and sero-positive rheumatoid arthritis (RA) patients. Methods Sixty-nine RA patients were enrolled into this study and their clinical data were recorded. The BlyS levels in plasma, frequency of T and B lymphocytes, as well as T-helper (Th) subgroups were compared between sero-negative and sero-positive RA patients. Furthermore, the correlations between clinical features and immunological features were analyzed. Results The plasma BlyS level in sero-negative RA was higher compared to the sero-positive RA patients (1.73 +/- 1.71 vs. 0.99 +/- 0.59 ng/mL, P < 0.05) and osteoarthritis (OA) patients (1.73 +/- 1.71 vs. 0.59 +/- 0.12 ng/mL, P < 0.05). Plasma BlyS level was correlated with disease activity score (DAS-28, erythrocyte sedimentation rate and C-reactive protein), but had no correlation with the titers of rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. The patients with more advanced changes in X-rays had high plasma BlyS levels. No significant differences in the frequency of T lymphocytes, Th subpopulations and B lymphocytes in peripheral blood were observed between sero-negative and sero-positive RA patients. Conclusions Plasma BlyS level was correlated with disease activity and radiological progress, which indicates that plasma BlyS level may become a useful biological marker to reflect DAS and to predict RA prognosis.

语种: 英语
WOS记录号: WOS:000310077300021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58714
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Beijing Univ, Hosp 1, Dept Rheumatol & Clin Immunol, Beijing 100034, Peoples R China

Recommended Citation:
Geng, Yan,Zhang, Zhuo-li. Comparative study on the level of B lymphocyte stimulator (BlyS) and frequency of lymphocytes between sero-negative and sero-positive rheumatoid arthritis patients[J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,2012,15(5):478-485.
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