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Renal impairment caused by chronic occupational chromate exposure
Wang, Tiancheng2; Jia, Guang1; Zhang, Ji3; Ma, Yanhui3; Feng, Weiyue4; Liu, Lanzheng3; Zhang, Ning3; Yan, Lei1; Wang, Xiang1; Zhang, Xueyan1; Liu, Zihong1; Du, Xianmei1; Zhen, Sen1
关键词Chromate Occupational exposure Renal impairment Urinary enzyme Urinary proteins
刊名INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
2011-04-01
DOI10.1007/s00420-010-0569-4
84期:4页:393-401
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]SERUM CYSTATIN-C ; STAINLESS-STEEL WELDERS ; URINARY-EXCRETION ; KIDNEY-FUNCTION ; HEXAVALENT CHROMIUM ; WORKERS ; DISEASE ; NEPHROTOXICITY ; NEPHROPATHY ; DYSFUNCTION
英文摘要

To determine the nephritic toxicity of chromate after chronic occupational exposure.

The environmental contamination was assessed by measuring the chromium (Cr) in 8-h airborne sampler. The integrated level of Cr was determined by Cr concentrations in the whole blood (WB-Cr) and the urine (U-Cr). The renal glomerular and tubule impairment was evaluated by determination of cystatin C (Cys-C) in the serum and microalbumin (mALB), urinary beta(2)-microglobulin (beta(2)M), N-acetyl-beta-d-glucosaminidase (NAG) activity in the urine.

The mean occupational exposure time to Cr was 12.86 years with average daily air level of 27.13 mu g/m(3) comparing to 0.11 mu g/m(3) of the background level. The WB-Cr and U-Cr were 23.49 mu g/L and 17.41 mu g/g creatinine (Cre), respectively in the chromate-exposed workers comparing to 3.32 mu g/L and 1.52 mu g/g Cre in the controls. The serum Cys-C and urinary mALB were significantly increased in the chromate-exposed workers. Exposure to Cr seems to induce an enhanced level of urinary NAG activity and beta(2)M concentration. The increased serum Cys-C concentration was positively correlated with the level of serum Cre. The U-Cr was positively correlated to the concentrations of urinary mALB, beta(2)M, and the activity of NAG.

Chronic occupational exposure to chromate causes comprehensive renal impairment though more severity could occur in the tubule than in the glomeruler.

语种英语
WOS记录号WOS:000288456000006
项目编号30571550 ; 2006BAI06B02 ; 200902006
资助机构National Natural Science Foundation of China ; National Science and Technical Supporting Program of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58716
专题北京大学公共卫生学院
北京大学临床肿瘤学院_肝胆胰外二科
作者单位1.Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China
2.Peking Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Tiancheng,Jia, Guang,Zhang, Ji,et al. Renal impairment caused by chronic occupational chromate exposure[J]. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,2011,84(4):393-401.
APA Wang, Tiancheng.,Jia, Guang.,Zhang, Ji.,Ma, Yanhui.,Feng, Weiyue.,...&Zhen, Sen.(2011).Renal impairment caused by chronic occupational chromate exposure.INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,84(4),393-401.
MLA Wang, Tiancheng,et al."Renal impairment caused by chronic occupational chromate exposure".INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 84.4(2011):393-401.
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