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学科主题: 公共卫生
题名:
Renal impairment caused by chronic occupational chromate exposure
作者: Wang, Tiancheng2; Jia, Guang1; Zhang, Ji3; Ma, Yanhui3; Feng, Weiyue4; Liu, Lanzheng3; Zhang, Ning3; Yan, Lei1; Wang, Xiang1; Zhang, Xueyan1; Liu, Zihong1; Du, Xianmei1; Zhen, Sen1
关键词: Chromate ; Occupational exposure ; Renal impairment ; Urinary enzyme ; Urinary proteins
刊名: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
发表日期: 2011-04-01
DOI: 10.1007/s00420-010-0569-4
卷: 84, 期:4, 页:393-401
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: SERUM CYSTATIN-C ; STAINLESS-STEEL WELDERS ; URINARY-EXCRETION ; KIDNEY-FUNCTION ; HEXAVALENT CHROMIUM ; WORKERS ; DISEASE ; NEPHROTOXICITY ; NEPHROPATHY ; DYSFUNCTION
英文摘要:

To determine the nephritic toxicity of chromate after chronic occupational exposure.

The environmental contamination was assessed by measuring the chromium (Cr) in 8-h airborne sampler. The integrated level of Cr was determined by Cr concentrations in the whole blood (WB-Cr) and the urine (U-Cr). The renal glomerular and tubule impairment was evaluated by determination of cystatin C (Cys-C) in the serum and microalbumin (mALB), urinary beta(2)-microglobulin (beta(2)M), N-acetyl-beta-d-glucosaminidase (NAG) activity in the urine.

The mean occupational exposure time to Cr was 12.86 years with average daily air level of 27.13 mu g/m(3) comparing to 0.11 mu g/m(3) of the background level. The WB-Cr and U-Cr were 23.49 mu g/L and 17.41 mu g/g creatinine (Cre), respectively in the chromate-exposed workers comparing to 3.32 mu g/L and 1.52 mu g/g Cre in the controls. The serum Cys-C and urinary mALB were significantly increased in the chromate-exposed workers. Exposure to Cr seems to induce an enhanced level of urinary NAG activity and beta(2)M concentration. The increased serum Cys-C concentration was positively correlated with the level of serum Cre. The U-Cr was positively correlated to the concentrations of urinary mALB, beta(2)M, and the activity of NAG.

Chronic occupational exposure to chromate causes comprehensive renal impairment though more severity could occur in the tubule than in the glomeruler.

语种: 英语
所属项目编号: 30571550 ; 2006BAI06B02 ; 200902006
项目资助者: National Natural Science Foundation of China ; National Science and Technical Supporting Program of China
WOS记录号: WOS:000288456000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58716
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China
2.Peking Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci, Beijing, Peoples R China

Recommended Citation:
Wang, Tiancheng,Jia, Guang,Zhang, Ji,et al. Renal impairment caused by chronic occupational chromate exposure[J]. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,2011,84(4):393-401.
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