|Renal impairment caused by chronic occupational chromate exposure|
|Wang, Tiancheng2; Jia, Guang1; Zhang, Ji3; Ma, Yanhui3; Feng, Weiyue4; Liu, Lanzheng3; Zhang, Ning3; Yan, Lei1; Wang, Xiang1; Zhang, Xueyan1; Liu, Zihong1; Du, Xianmei1; Zhen, Sen1|
|关键词||Chromate Occupational exposure Renal impairment Urinary enzyme Urinary proteins|
|刊名||INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||SERUM CYSTATIN-C ; STAINLESS-STEEL WELDERS ; URINARY-EXCRETION ; KIDNEY-FUNCTION ; HEXAVALENT CHROMIUM ; WORKERS ; DISEASE ; NEPHROTOXICITY ; NEPHROPATHY ; DYSFUNCTION|
To determine the nephritic toxicity of chromate after chronic occupational exposure.
The environmental contamination was assessed by measuring the chromium (Cr) in 8-h airborne sampler. The integrated level of Cr was determined by Cr concentrations in the whole blood (WB-Cr) and the urine (U-Cr). The renal glomerular and tubule impairment was evaluated by determination of cystatin C (Cys-C) in the serum and microalbumin (mALB), urinary beta(2)-microglobulin (beta(2)M), N-acetyl-beta-d-glucosaminidase (NAG) activity in the urine.
The mean occupational exposure time to Cr was 12.86 years with average daily air level of 27.13 mu g/m(3) comparing to 0.11 mu g/m(3) of the background level. The WB-Cr and U-Cr were 23.49 mu g/L and 17.41 mu g/g creatinine (Cre), respectively in the chromate-exposed workers comparing to 3.32 mu g/L and 1.52 mu g/g Cre in the controls. The serum Cys-C and urinary mALB were significantly increased in the chromate-exposed workers. Exposure to Cr seems to induce an enhanced level of urinary NAG activity and beta(2)M concentration. The increased serum Cys-C concentration was positively correlated with the level of serum Cre. The U-Cr was positively correlated to the concentrations of urinary mALB, beta(2)M, and the activity of NAG.
Chronic occupational exposure to chromate causes comprehensive renal impairment though more severity could occur in the tubule than in the glomeruler.
|项目编号||30571550 ; 2006BAI06B02 ; 200902006|
|资助机构||National Natural Science Foundation of China ; National Science and Technical Supporting Program of China|
|作者单位||1.Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China|
2.Peking Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci, Beijing, Peoples R China
|Wang, Tiancheng,Jia, Guang,Zhang, Ji,et al. Renal impairment caused by chronic occupational chromate exposure[J]. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,2011,84(4):393-401.|
|APA||Wang, Tiancheng.,Jia, Guang.,Zhang, Ji.,Ma, Yanhui.,Feng, Weiyue.,...&Zhen, Sen.(2011).Renal impairment caused by chronic occupational chromate exposure.INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,84(4),393-401.|
|MLA||Wang, Tiancheng,et al."Renal impairment caused by chronic occupational chromate exposure".INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 84.4(2011):393-401.|