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学科主题: 基础医学
题名:
Mechanism of BDE209-induced impaired glucose homeostasis based on gene microarray analysis of adult rat liver
作者: Zhang, Zhan1; Sun, Zhen-Zhen1; Xiao, Xue1; Zhou, Shixin2,3; Wang, Xi-Chen1; Gu, Jun1; Qiu, Liang-Lin1; Zhang, Xu-Hui1; Xu, Qiujin4; Zhen, Binghui4; Wang, Xinru1; Wang, Shou-Lin1
关键词: BDE209 ; Glucose homeostasis ; Oxidative stress ; Gene microarray ; Pathway analysis
刊名: ARCHIVES OF TOXICOLOGY
发表日期: 2013-08-01
DOI: 10.1007/s00204-013-1059-8
卷: 87, 期:8, 页:1557-1567
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: OXIDATIVE STRESS ; T-CELLS ; EXPOSURE ; PATHWAY ; ORGANIZATION ; PREVALENCE ; PROFILES ; NETWORKS ; TOXICITY ; BIOLOGY
英文摘要:

Several persistent organic pollutants are reported to be potentially associated with the risk of human diabetes that has become rapidly epidemic in China currently. 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE209) is commercially most important both in the production and in the use of polybrominated diphenyl ethers (PBDEs). It might bioaccumulate in wildlife and human and is the only PBDEs mixture still used today. In the present study, male adult rats treated with BDE209 (0, 0.05, 1, and 20 mg/kg) for 8 weeks were used to explore the effects of BDE209 on glucose homeostasis and possible mechanisms; 0.05 mg/kg of BDE209 induced dose-related hyperglycemia. Then, we performed the full-genome gene expression microarrays, gene ontology analysis, and pathway analysis in this group and control. BDE209 induced 1,257 liver gene transcript changes, and 18 canonical pathways were significantly enriched. Four of them were involved in immune diseases, including autoimmune thyroid disease, graft-versus-host disease, allograft rejection, and type I diabetes mellitus (T1MD), which was confirmed by the decrease in serum insulin. Subsequently, gene act network and gene co-expression network found that some MHC molecules and TNF-alpha were involved in T1DM pathway, which was then confirmed by the increase in serum TNF-alpha. Additionally, reduced glutathione and superoxide dismutase in plasma indicated that oxidative damage might partly contribute to BDE209-induced hyperglycemia. The results of this study provide some new experimental evidence that the exposure to high levels of BDE209 may contribute to the onset of diabetes in human populations. Further work needs to be done to confirm this link.

语种: 英语
所属项目编号: 200909054 ; 2009CB941701 ; 81172695 ; 30972508 ; 20093234110002 ; DG216D5047
项目资助者: Environmental Protection Research Special Funds for Public Welfare Projects ; National 973 program ; National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education of China ; Six talents peak project of Jiangsu province ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), China
WOS记录号: WOS:000323652100005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58720
Appears in Collections:基础医学院_北京大学干细胞研究中心_期刊论文

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作者单位: 1.Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing 211166, Jiangsu, Peoples R China
2.Peking Univ Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100083, Peoples R China
3.Peking Univ Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
4.Chinese Res Inst Environm Sci, Lake Res Ctr, Beijing 100012, Peoples R China

Recommended Citation:
Zhang, Zhan,Sun, Zhen-Zhen,Xiao, Xue,et al. Mechanism of BDE209-induced impaired glucose homeostasis based on gene microarray analysis of adult rat liver[J]. ARCHIVES OF TOXICOLOGY,2013,87(8):1557-1567.
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