|Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI|
|Wang, Jing1; Zhang, Yudong3; Yang, Xuedong3; Wang, Xiaoying1,3; Zhang, Jue1,2; Fang, Jing1,2; Jiang, Xuexiang3|
|关键词||Arterial spin labeling furosemide renal blood flow autoregulation|
|WOS标题词||Science & Technology|
|类目[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||BLOOD-FLOW AUTOREGULATION ; CEREBRAL PERFUSION ; LOOP DIURETICS ; MECHANISMS ; FILTRATION ; RATS ; VASODILATION ; RELAXATION ; MEDULLARY ; EXCRETION|
Rationale and Objectives: The aim of this study was to investigate the short-term effects of furosemide on renal perfusion by using arterial spin labeling (ASL) magnetic resonance imaging.
Materials and Methods: Eleven healthy human subjects were enrolled in the study. The measurement of renal blood flow (RBF) was performed by applying an ASL technique with flow-sensitive alternating inversion recovery spin preparation and a single-shot fast spin-echo imaging strategy on a 3.0-T magnetic resonance scanner. For all subjects, the ASL magnetic resonance images were obtained before agent injection as a baseline scan. Then 20 mg of furosemide was injected intravenously. Postfurosemide ASL images were acquired following administration to evaluate the renal hemodynamic response.
Results: Postinjection scans showed that cortical RBF decreased from 366.59 +/- 41.19 mL/100 g/min at baseline to 314.33 +/- 48.83 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .04 vs baseline), and medullary RBF decreased from 118.59 +/- 24.69 mL/100 g/min at baseline to 97.38 +/- 18.40 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .01 vs baseline). There was a negative correlation between the furosemide-induced diuretic effect and the reduction of RBF (Spearman′s r = -0.61).
Conclusions: The dominant hemodynamic effect of furosemide on the kidney is associated with a decrease in both cortical and medullary blood perfusion. Furthermore, the quantitative ASL technique may provide an alternative way to noninvasively monitor the change in renal function due to furosemide administration.
|作者单位||1.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China|
2.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
|Wang, Jing,Zhang, Yudong,Yang, Xuedong,et al. Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI[J]. ACADEMIC RADIOLOGY,2012,19(10):1194-1200.|
|APA||Wang, Jing.,Zhang, Yudong.,Yang, Xuedong.,Wang, Xiaoying.,Zhang, Jue.,...&Jiang, Xuexiang.(2012).Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI.ACADEMIC RADIOLOGY,19(10),1194-1200.|
|MLA||Wang, Jing,et al."Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI".ACADEMIC RADIOLOGY 19.10(2012):1194-1200.|