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学科主题: 临床医学
题名:
Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI
作者: Wang, Jing1; Zhang, Yudong3; Yang, Xuedong3; Wang, Xiaoying1,3; Zhang, Jue1,2; Fang, Jing1,2; Jiang, Xuexiang3
关键词: Arterial spin labeling ; furosemide ; renal blood flow ; autoregulation
刊名: ACADEMIC RADIOLOGY
发表日期: 2012-10-01
DOI: 10.1016/j.acra.2012.04.021
卷: 19, 期:10, 页:1194-1200
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: BLOOD-FLOW AUTOREGULATION ; CEREBRAL PERFUSION ; LOOP DIURETICS ; MECHANISMS ; FILTRATION ; RATS ; VASODILATION ; RELAXATION ; MEDULLARY ; EXCRETION
英文摘要:

Rationale and Objectives: The aim of this study was to investigate the short-term effects of furosemide on renal perfusion by using arterial spin labeling (ASL) magnetic resonance imaging.

Materials and Methods: Eleven healthy human subjects were enrolled in the study. The measurement of renal blood flow (RBF) was performed by applying an ASL technique with flow-sensitive alternating inversion recovery spin preparation and a single-shot fast spin-echo imaging strategy on a 3.0-T magnetic resonance scanner. For all subjects, the ASL magnetic resonance images were obtained before agent injection as a baseline scan. Then 20 mg of furosemide was injected intravenously. Postfurosemide ASL images were acquired following administration to evaluate the renal hemodynamic response.

Results: Postinjection scans showed that cortical RBF decreased from 366.59 +/- 41.19 mL/100 g/min at baseline to 314.33 +/- 48.83 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .04 vs baseline), and medullary RBF decreased from 118.59 +/- 24.69 mL/100 g/min at baseline to 97.38 +/- 18.40 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .01 vs baseline). There was a negative correlation between the furosemide-induced diuretic effect and the reduction of RBF (Spearman′s r = -0.61).

Conclusions: The dominant hemodynamic effect of furosemide on the kidney is associated with a decrease in both cortical and medullary blood perfusion. Furthermore, the quantitative ASL technique may provide an alternative way to noninvasively monitor the change in renal function due to furosemide administration.

语种: 英语
WOS记录号: WOS:000309193700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58724
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
2.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Jing,Zhang, Yudong,Yang, Xuedong,et al. Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI[J]. ACADEMIC RADIOLOGY,2012,19(10):1194-1200.
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