IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI
Wang, Jing1; Zhang, Yudong3; Yang, Xuedong3; Wang, Xiaoying1,3; Zhang, Jue1,2; Fang, Jing1,2; Jiang, Xuexiang3
关键词Arterial spin labeling furosemide renal blood flow autoregulation
刊名ACADEMIC RADIOLOGY
2012-10-01
DOI10.1016/j.acra.2012.04.021
19期:10页:1194-1200
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]BLOOD-FLOW AUTOREGULATION ; CEREBRAL PERFUSION ; LOOP DIURETICS ; MECHANISMS ; FILTRATION ; RATS ; VASODILATION ; RELAXATION ; MEDULLARY ; EXCRETION
英文摘要

Rationale and Objectives: The aim of this study was to investigate the short-term effects of furosemide on renal perfusion by using arterial spin labeling (ASL) magnetic resonance imaging.

Materials and Methods: Eleven healthy human subjects were enrolled in the study. The measurement of renal blood flow (RBF) was performed by applying an ASL technique with flow-sensitive alternating inversion recovery spin preparation and a single-shot fast spin-echo imaging strategy on a 3.0-T magnetic resonance scanner. For all subjects, the ASL magnetic resonance images were obtained before agent injection as a baseline scan. Then 20 mg of furosemide was injected intravenously. Postfurosemide ASL images were acquired following administration to evaluate the renal hemodynamic response.

Results: Postinjection scans showed that cortical RBF decreased from 366.59 +/- 41.19 mL/100 g/min at baseline to 314.33 +/- 48.83 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .04 vs baseline), and medullary RBF decreased from 118.59 +/- 24.69 mL/100 g/min at baseline to 97.38 +/- 18.40 mL/100 g/min at 10 minutes after the administration of furosemide (paired t test, P = .01 vs baseline). There was a negative correlation between the furosemide-induced diuretic effect and the reduction of RBF (Spearman′s r = -0.61).

Conclusions: The dominant hemodynamic effect of furosemide on the kidney is associated with a decrease in both cortical and medullary blood perfusion. Furthermore, the quantitative ASL technique may provide an alternative way to noninvasively monitor the change in renal function due to furosemide administration.

语种英语
WOS记录号WOS:000309193700005
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58724
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
2.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jing,Zhang, Yudong,Yang, Xuedong,et al. Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI[J]. ACADEMIC RADIOLOGY,2012,19(10):1194-1200.
APA Wang, Jing.,Zhang, Yudong.,Yang, Xuedong.,Wang, Xiaoying.,Zhang, Jue.,...&Jiang, Xuexiang.(2012).Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI.ACADEMIC RADIOLOGY,19(10),1194-1200.
MLA Wang, Jing,et al."Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by ASL-MRI".ACADEMIC RADIOLOGY 19.10(2012):1194-1200.
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