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学科主题: 基础医学
题名:
New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism
作者: Bankir, Lise1; Yang, Baoxue2,3
关键词: active secretion ; glucose transport ; lactate ; renal medulla ; SGLT1 ; urea transport
刊名: KIDNEY INTERNATIONAL
发表日期: 2012-06-01
DOI: 10.1038/ki.2012.67
卷: 81, 期:12, 页:1179-1198
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: MEDULLARY COLLECTING DUCT ; PERFUSED RAT LIVER ; BLADDER PERMEABILITY BARRIER ; GLOMERULAR-FILTRATION-RATE ; TRANSPORTER KNOCKOUT MICE ; RENAL PROXIMAL TUBULE ; THIN DESCENDING-LIMB ; LOW-PROTEIN DIET ; BRATTLEBORO RATS ; MAMMALIAN KIDNEY
英文摘要:

The mechanism by which urine is concentrated in the mammalian kidney remains incompletely understood. Urea is the dominant urinary osmole in most mammals and may be concentrated a 100-fold above its plasma level in humans and even more in rodents. Several facilitated urea transporters have been cloned. The phenotypes of mice with deletion of the transporters expressed in the kidney have challenged two previously well-accepted paradigms regarding urea and sodium handling in the renal medulla but have provided no alternative explanation for the accumulation of solutes that occurs in the inner medulla. In this review, we present evidence supporting the existence of an active urea secretion in the pars recta of the proximal tubule and explain how it changes our views regarding intrarenal urea handling and UT-A2 function. The transporter responsible for this secretion could be SGLT1, a sodium-glucose cotransporter that also transports urea. Glucagon may have a role in the regulation of this secretion. Further, we describe a possible transfer of osmotic energy from the outer to the inner medulla via an intrarenal Cori cycle converting glucose to lactate and back. Finally, we propose that an active urea transporter, expressed in the urothelium, may continuously reclaim urea that diffuses out of the ureter and bladder. These hypotheses are all based on published findings. They may not all be confirmed later on, but we hope they will stimulate further research in new directions.

语种: 英语
所属项目编号: 367 ; 872 ; 30870921 ; 81170632
项目资助者: Institut National de la Sante et de la Recherche Medicale ; National Natural Science Foundation of China
WOS记录号: WOS:000304973000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58726
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Ctr Rech Cordeliers, INSERM, U872, Equipe 2, F-75006 Paris, France
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China
3.Minist Educ Res, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China

Recommended Citation:
Bankir, Lise,Yang, Baoxue. New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism[J]. KIDNEY INTERNATIONAL,2012,81(12):1179-1198.
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