IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism
Bankir, Lise1; Yang, Baoxue2,3
关键词active secretion glucose transport lactate renal medulla SGLT1 urea transport
刊名KIDNEY INTERNATIONAL
2012-06-01
DOI10.1038/ki.2012.67
81期:12页:1179-1198
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]MEDULLARY COLLECTING DUCT ; PERFUSED RAT LIVER ; BLADDER PERMEABILITY BARRIER ; GLOMERULAR-FILTRATION-RATE ; TRANSPORTER KNOCKOUT MICE ; RENAL PROXIMAL TUBULE ; THIN DESCENDING-LIMB ; LOW-PROTEIN DIET ; BRATTLEBORO RATS ; MAMMALIAN KIDNEY
英文摘要

The mechanism by which urine is concentrated in the mammalian kidney remains incompletely understood. Urea is the dominant urinary osmole in most mammals and may be concentrated a 100-fold above its plasma level in humans and even more in rodents. Several facilitated urea transporters have been cloned. The phenotypes of mice with deletion of the transporters expressed in the kidney have challenged two previously well-accepted paradigms regarding urea and sodium handling in the renal medulla but have provided no alternative explanation for the accumulation of solutes that occurs in the inner medulla. In this review, we present evidence supporting the existence of an active urea secretion in the pars recta of the proximal tubule and explain how it changes our views regarding intrarenal urea handling and UT-A2 function. The transporter responsible for this secretion could be SGLT1, a sodium-glucose cotransporter that also transports urea. Glucagon may have a role in the regulation of this secretion. Further, we describe a possible transfer of osmotic energy from the outer to the inner medulla via an intrarenal Cori cycle converting glucose to lactate and back. Finally, we propose that an active urea transporter, expressed in the urothelium, may continuously reclaim urea that diffuses out of the ureter and bladder. These hypotheses are all based on published findings. They may not all be confirmed later on, but we hope they will stimulate further research in new directions.

语种英语
WOS记录号WOS:000304973000006
项目编号367 ; 872 ; 30870921 ; 81170632
资助机构Institut National de la Sante et de la Recherche Medicale ; National Natural Science Foundation of China
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58726
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Ctr Rech Cordeliers, INSERM, U872, Equipe 2, F-75006 Paris, France
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China
3.Minist Educ Res, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Bankir, Lise,Yang, Baoxue. New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism[J]. KIDNEY INTERNATIONAL,2012,81(12):1179-1198.
APA Bankir, Lise,&Yang, Baoxue.(2012).New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism.KIDNEY INTERNATIONAL,81(12),1179-1198.
MLA Bankir, Lise,et al."New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism".KIDNEY INTERNATIONAL 81.12(2012):1179-1198.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
New insights into ur(802KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Bankir, Lise]的文章
[Yang, Baoxue]的文章
百度学术
百度学术中相似的文章
[Bankir, Lise]的文章
[Yang, Baoxue]的文章
必应学术
必应学术中相似的文章
[Bankir, Lise]的文章
[Yang, Baoxue]的文章
相关权益政策
暂无数据
收藏/分享
文件名: New insights into urea and glucose handling by the kidney, and the urine concentrating mechanism.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。