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学科主题: 临床医学
题名:
Change of extracellular ascorbic acid in the brain cortex following ice water vestibular stimulation: an on-line electrochemical detection coupled with in vivo microdialysis sampling for guinea pigs
作者: Zhang Na1; Liu Jun-Xiu1; Ma Fu-Rong1; Yu Li-Sheng2; Lin Yu-Qing3; Liu Kun3; Mao Lan-Qun3
关键词: ascorbic acid ; caloric vestibular stimulation ; primary somatosensory area ; in vivo microdialysis ; on-line electrochemical detection
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2008-06-20
卷: 121, 期:12, 页:1120-1125
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: NUCLEUS NEURONS ; RAT STRIATUM ; NITRIC-OXIDE ; INNER-EAR ; GLUTAMATE ; ISCHEMIA ; SYSTEM ; CYTOARCHITECTONICS ; INHIBITION ; THERAPY
英文摘要:

Background Ascorbic acid (AA) represents one of the most important enzyme co-factors, antioxidants and neuromodulators and plays an important role in the cerebral system. Increasing evidence has suggested that AA could treat certain kinds of vertigo diseases such as Meniere′s disease. To elucidate the neurochemical functions associated with AA in vertigo, the change of extracellular AA in the brain cortex following caloric vestibular stimulation (CVS) was evaluated.

Methods An on-line electrochemical detection was coupled with in vivo microdialysis to continuously monitor the change of extracellular AA in the primary somatosensory (SI) area of guinea pigs following a caloric vestibular stimulation. Sixteen guinea pigs were divided into three groups, i.e., experimental group with irrigation of the ear canal with ice water (0 degrees C) (n=8), and two control groups, one with irrigation of the ear canal with warm water (38 degrees C) (n=4) and the other with irrigation of the auricle with ice water (n=4).

Results In the experimental group, the ice water irrigation of the left external ear canal induced a horizontal nystagmus towards the right side lasting about 45 seconds. No nystagmus was induced by warm water irrigation of the external ear canal or by ice water irrigation of the auricle. The extracellular AA concentration significantly increased following the ice water vestibular stimulation, reaching a maximum of (130 +/- 20)% (n=8) of the basal dialysate level (2.61 +/- 0.92) mu mol/L (n=8), lasting at least for an hour. AA level did not change distinctly after the irrigation of the left external ear canal with warm water or the irrigation of the auricle with ice water.

Conclusions The concentration of extracellular AA in the brain cortex of the SI area increased following the ice water vestibular stimulation. This demonstration may be useful for the investigation of the neurochemical processes associated with AA in the process of vertigo.

语种: 英语
WOS记录号: WOS:000256943800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58731
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Otorhinolaryngol, Beijing 100044, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China

Recommended Citation:
Zhang Na,Liu Jun-Xiu,Ma Fu-Rong,et al. Change of extracellular ascorbic acid in the brain cortex following ice water vestibular stimulation: an on-line electrochemical detection coupled with in vivo microdialysis sampling for guinea pigs[J]. CHINESE MEDICAL JOURNAL,2008,121(12):1120-1125.
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